Synergistic effect of azole antimycotics (clotrimazole and fluconazole) and natural substances

Martin Kuruc, Eva Čonková

Čes. slov. farm. 2017, 66(4):164-167 | DOI: 10.36290/csf.2017.025  

Nowadays the treatment of fungal infections is difficult due to increasing resistance of fungal pathogens to antimycotics. The efficacy of antimycotics can be increased by a proper combination of commercial drugs and natural substances. The 100% antimycotic activity was found using susceptibility testing of Candida albicans yeasts on clotrimazole alone and in combination with tea tree oil, or with a multicomponent preparation containing cannabis oil and various essential oils and in combination with propolis tincture. Combination of natural substances with fluconazole seems to be also prospective. Fluconazole alone achieved an antifungal activity...

Cholinesterase activity assays and their use in the diagnosis of various pathological states including poisoning by neurotoxic agents

Miroslav Pohanka

Čes. slov. farm. 2017, 66(4):147-153 | DOI: 10.36290/csf.2017.022  

Cholinesterases are enzymes important for some nerve transmissions where the enzyme acetylcholinesterase plays a crucial role. The second enzyme, butyrylcholinesterase, is not necessary for the neurotransmission but it is involved in some detoxification reactions. A survey of literature, a discussion of diagnostic importance and the methods for an activity assay are presented in this review article. Liver failures, exposure to neurotoxic compounds, genetic dispositions are outlined here. In the field of assays, spectrophotometric, colorimetric and electrochemical tests are discussed.

Possibilities of using sodium hyaluronate in pharmaceutical and medical fields

Veronika Pechová, Jan Gajdziok

Čes. slov. farm. 2017, 66(4):154-159 | DOI: 10.36290/csf.2017.023  

Sodium hyaluronate represents a contemporary biomaterial with broad use in different pharmaceutical and medical fields. It is a physiological glycosaminoglycan, which occurs primarily in the extracellular matrix, synovial fluid, cartilage, epidermis and vitreous body. It plays a critical role as a signalling molecule in immunological processes, cell motility and wound healing, and it possesses antioxidant activity. It is used in many fields of medicine if supplementation of hyaluronan is needed or in the cases of preventive and therapeutic interventions. Thanks to its moisturizing, regenerative and protective effects it is used in cosmetics as well.

Specifics of some calcium salts in intravenous therapy of hypocalcemia and their further use

Michal Janů

Čes. slov. farm. 2017, 66(4):160-163 | DOI: 10.36290/csf.2017.024  

Hypocalcemia is a serious condition which has a major impact on the transmission of nerve impulses, contraction and relaxation of muscles (including myocardial) and pathological secretion of some hormones. The basic causal treatment is the parenteral administration of calcium, namely calcium gluconate, calcium chloride or calcium gluceptate. Parenteral formulations of these compounds must meet pharmacopoeial requirements, including the aluminum content limit. Each of these molecules has its specific properties that predict their clinical use. In addition to hypocalcemia, they are used to influence a variety of other conditions, such as fluoride or...

Simplicia and medical containers from the Jesuit pharmacy in Telč

Anna Hamrlová

Čes. slov. farm. 2017, 66(4):168-176 | DOI: 10.36290/csf.2017.026  

The Jesuit pharmacy in Telč was founded after 1657 within the premises of the Jesuit cloister; it survived the dissolution of Jesuits in 1773 and thanks to its purchase by the last pharmacist Ignac Lyro it was relocated to one of the houses in the square. During the stocktaking of the property and its sale, a detailed inventory of pharmacy equipment was recorded, including cabinets, laboratory tools, ingredients or drugs. The inventory is divided into parts of ingredients and prepared medications, the last lists recording the tools and containers for its preparation, production and preservation. The ingredients contain various parts of plants, minerals,...

Nové knihy

J. Čižmárik

Čes. slov. farm. 2017, 66(4):186  

Brněnské výstavy herbářů

Miroslava Šudomová, Sherif T. S. Hassan

Čes. slov. farm. 2017, 66(4):184  

XLIII. lekárnické dni Lekárnickej sekcie Slovenskej farmaceutickej spoločnosti, venované 65. výročiu vzniku Farmaceutickej fakulty Univerzity Komenského v Bratislave, boli v Košiciach

Čes. slov. farm. 2017, 66(4):177-183