Influence of the mesh of extrusion dies on the properties of cores intended for the preparation of pellets with controlled glucose release

Sylvie Pavloková, Aleš Franc, Jan Muselík, Dana Sabadková, Pavlína Kopecká, David Neumann

Čes. slov. farm. 2016, 65(1):22-27 | DOI: 10.36290/csf.2016.004  

Diabetes mellitus and its compensation are accompanied by serious complications. One of them is hypoglycaemia, which occurs in patients treated with insulin and/or certain peroral antidiabetics. Hypoglycaemic episodes can be prevented by a dosage form with controlled release of glucose. The pellet cores of four compositions and three different sizes corresponding to the diameter of extrusion screen mesh (0.6, 0.8, and 1.0 mm) were prepared for this purpose. The cores contain 75-80% of glucose combined with one of the following osmotically or swellable active agents: croscarmellose sodium (ADS), a mixture of microcrystalline cellulose and carmellose...

The relationship of lipid imbalance and chronic inflammation mediated by PPAR

Tomáš Čavojský, František Bilka, Ingrid Pauliková

Čes. slov. farm. 2016, 65(1):3-9 | DOI: 10.36290/csf.2016.001  

Obesity is a serious metabolic disease that threatens patients with increasing incidence of the metabolic, cardiovascular, cancer^1-3) and other associated, especially autoimmune diseases. It increases significantly the morbidity and mortality of patients and reduces quality of their life.The imbalance between lipolysis and lipogenesis results in a number of metabolic related disorders at the different regulatory levels of transcription, translation, and/or activity of enzymes. One of the extensively studied areas in regulating lipogenesis, often accompanied by inflammation, is a peroxisome proliferator activated receptors (PPARs), especially...

Antimicrobial, antiparasitic and anticancer properties of Hibiscus sabdariffa (L.) and its phytochemicals: in vitro and in vivo studies

Sherif T. S. Hassan, Katefiina Berchová, Miroslava Šudomová

Čes. slov. farm. 2016, 65(1):10-14 | DOI: 10.36290/csf.2016.002  

In the last few decades, Hibiscus sabdariffa L. (Malvaceae; H. sabdariffa) has gained much attention in research field because of its potentially useful bioactivity as well as a great safety and tolerability. For decades, microbial, parasitic and cancer diseases remain a serious threat to human health and animals as well. To treat such diseases, a search for new sources such as plants that provide various bioactive compounds useful in the treatment of several physiological conditions is urgently needed, since most of the drugs currently used in the therapy have several undesirable side effects, toxicity, and drug resistance. In this paper,...

Oral films as perspective dosage form

Veronika Walicová, Jan Gajdziok

Čes. slov. farm. 2016, 65(1):15-21 | DOI: 10.36290/csf.2016.003  

Oral films, namely buccal mucoadhesive films and orodispersible films represent innovative formulations for administration of a wide range of drugs. Oral films show many advantageous properties and are intended for systemic drug delivery or for local treatment of the oral mucosa. In both cases, the film represents a thin layer, which could be intended to adhere to the oral mucosa by means of mucoadhesion; or to rapid dissolution and subsequent swallowing without the need of liquid intake, in the case of orodispersible films. Main constitutive excipients are film-forming polymers, which must in the case of mucoadhesive forms remain on the mucosa within...

Farmakognózia. Biologicky aktívne rastlinné metabolity a ich zdroje

J. Čižmárik

Čes. slov. farm. 2016, 65(1):39  

35. technologické dni a pohľad do histórie tohto podujatia

D. Matušová, K. Gardavská, M. Čuchorová

Čes. slov. farm. 2016, 65(1):36-38  

Potential anticancer agent hypericin and its model compound emodin: interaction with DNA

Jana Staničová, Valéria Verebová, Alena Strejčková

Čes. slov. farm. 2016, 65(1):28-31  

Development of a spectrophotometric method for carmoisine determination in quality control of equipment cleaning

Anna Materiienko, Volodymyr Grudko, Victoriya Georgiyants

Čes. slov. farm. 2016, 65(1):32-33  

Thin-layer chromatography application for the standardization of Sophora flowers

Anna Kriukova, Inna Vladymyrova

Čes. slov. farm. 2016, 65(1):34-35