Magistral prepared lidocaine-gel for topical aplication on skin

Zbyněk Sklenář, Kateřina Horáčková, Hana Bakhouche, Ondřej Slanař

Čes. slov. farm. 2012, 61(4):163-168  

Due to a limited availability of industrially manufactured products containing local anesthetics for skin application and an increased demand for lidocaine-containing gel applicable prior to a product containing capsaicin for neuropathic pain treatment, it is necessary to prepare a topical semi-solid preparation containing the local anesthetic in pharmacies. Our aim was to create a mixed system of a hydrophilic gel with the emulsified drug, using excipients to decrease the lidocaine melting point, thereby creating a eutectic mixture with a high concentration of lidocaine in the oil phase. Based on bibliographic data, thymol creating a binary eutectic...

New pharmaceutical insights related to the pathways of PUFAs

Marek Obložinský, Mária Pekárová, Peter Hoffman, Lýdia Bezáková

Čes. slov. farm. 2012, 61(4):139-143  

The fatty acyl structure represents the major lipid building block of practically all lipids and therefore is one of the most fundamental categories of these molecules. Fatty acids (FAs) differ particularly in their chain length, number of double bonds and position of the bonds in the chain. The number of double bonds in the unsaturated molecule of FA distinguishes monounsaturated FAs (MUFAs) and polyunsaturated FAs (PUFAs). In the living cell PUFAs represent the dominant substrates for the formation of biologically active compounds - octadecanoids, eicosanoids and docosanoids - classified as oxylipins or as PUFAnoids. The present review focuses only...

Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease

Ondřej Benek, Kamil Musílek, Kamil Kuča

Čes. slov. farm. 2012, 61(4):144-149  

The amyloid-ß peptide (Aß) has been associated with Alzheimer's disease (AD) for some time. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for main Aß toxicity. Nowadays, this hypothesis is outdated and soluble intracellular Aß forms and their effects within the cell have come into the centre of attention. There are many intracellular proteins interacting with Aß including the mitochondrial enzyme amyloid-binding alcohol dehydrogenase (ABAD). The interaction between ABAD and Aß impairs mitochondrial functions and ultimately results in cell death. In...

Where does the development of new antituberculotics aim at?

Karel Waisser

Čes. slov. farm. 2012, 61(4):150-158  

Several research teams in the Czech and Slovak Republics are oriented on the development of new antitubeculotics. The present article is based mainly on the information from the Chemical Abstracts from the year 2011 and the beginning of the year 2012. It is a selection from almost three thousand reports aiming to help our scientists. The article presents topical information which may be of interest to several pharmaceutical professions.

Standard prescriptions for the formulation of medicinal preparations in pharmacies V. The collection Dermatologische Magistralrezepturen der Schweiz

Jan Šubert, Jozef Kolář

Čes. slov. farm. 2012, 61(4):159-162  

The paper deals with the content of the collection Dermatologische Magistralrezepturen der Schweiz (DEMARES) and the prescriptions from this collection which can be potentially usable in the innovations and standardization of the prescriptions of dermatologic medicinal preparations formulated in pharmacies in the Czech Republic. Another possible use of the collection DEMARES is for the revision of the National Section of the Czech Pharmacopoeia.

Our medicinal preparations in the mid-19th century. Part I - Introduction and chemical preparations

Pavel Drábek

Čes. slov. farm. 2012, 61(4):172-177  

The paper deals with the development of the first editions of the Austrian Pharmacopoeia, Pharmacopoea Austriaca, since its origin in the year 1812. It demonstrates its gradual retardation in the period when nearly all medicinal substances had to be prepared only in pharmacies. The conception was changed as late as 1855 in the Fifth Edition, when it was allowed to buy many medicinal substances from producers or wholesalers. At the same time, requirements for organoleptic properties and chemical purity began to be introduced. The present communication also deals with the chemical drugs used in the mid-19^th century and is based on a...

Our medicinal preparations in the mid-19th century. Part II - galenical preparations

Pavel Drábek

Čes. slov. farm. 2012, 61(4):178-184  

This part discusses the galenical preparations in the supplemented Fourth Edition of the Austrian Pharmacopoeia (1836) and compares them with the preparations presented in the Fifth Edition (1855). These preparations are divided, according to their consistence, into three groups - liquid, semi-solid and solid. The text also presents the then Czech terms according to A. Jandouš. The discussion summarizes the differences between the both mentioned editions of the Austrian Pharmacopoeia and some other peculiarities are confronted with other professional literature of the period.

XXXIV. pracovní dny Radiofarmaceutické sekce České společnosti nukleární medicíny ČLS JEP. Mladá Boleslav, 13.-15. června 2012

Čes. slov. farm. 2012, 61(4):185-194  

Prof. RNDr. Bohumil Sikyta, DrSc. jubiluje

Jiřina Spilková, Jaroslav Dušek

Čes. slov. farm. 2012, 61(4):195-196  

PharmDr. Jozef Német, jubiluje

J. Čižmárik

Čes. slov. farm. 2012, 61(4):196-197  

Formulation of salvia-containing gels

Zuzana Vitková, Petra Herdová, Alexandra Kodadová, Jana Šeligová, Daniel Grančai, Dominika Poláková

Čes. slov. farm. 2012, 61(4):169-171  

The trend during the past years is to prefer natural drugs to synthetically prepared medicines. Due to its important antiphlogistic, antiseptic and antihidrotic effects, Salvia officinalis L. has a wide use in medicine, pharmacy and cosmetics in various dosage forms. The aim of this research was the formulation of Salvia officinalis L. in the form of a tincture to hydrogels. Gels were parallelly prepared on the basis of the natural polymer chitosan and the synthetic polymer Carbopol^® 940. The evaluation was focused on the influence of the anionic polymer and the cationic polymer in different concentrations on hydrogel flow...