Časopis Česká a slovenská farmacie při vstupu do roku 2012

Čes. slov. farm. 2012, 61(1):3  

Stability testing of alginate-chitosan films

Miloslava Rabišková, Kateřina Dvořáčková, Lenka Kofroňová

Čes. slov. farm. 2012, 61(1):26-33  

Pellets containing rutin prepared by the extrusion/spheronization method were coated with sodium alginate-chitosan film. Important quality parameters in the pellets before coating were determined, and after coating the dissolution profiles of the drug were evaluated in dissolution media of the pH corresponding to the conditions in the gastrointestinal tract. Samples of coated pellets were located in the boxes for stability testing under different conditions, i.e. 25 °C and 60% of relative humidity (RH); 30 °C and 65% RH and 40 °C and 75% RH. After 1, 3, 6, 9 and 12 months (or 1, 3 and 6 months), the dissolution test was repeated and compared with the...

Compatibility of phosphates with calcium salts in parenteral nutrition

Michal Janů, Marek Vecka, Ruta Masteiková, Jurga Bernatonienė

Čes. slov. farm. 2012, 61(1):34-39  

When making prescriptions for total parenteral nutrition (TPN) it is necessary to take into consideration also substitution with calcium and phosphorus. Under some clinical conditions, or in certain groups of patients, it is necessary to supply these substances in high doses with a reduced volume, which due to mutual interactions may be problematic. This experimental paper therefore examined the compatibility of commercially available or individual preparations containing the compounds of calcium and phosphorus. These preparations were examined in a mixture with clinically employed solutions of amino acids or with solutions of glucose. The evaluation...

Monitoring of effectiveness of some preventive measures against influenza

Lucia Masaryková, Tomáš Baláži, Magdaléna Fulmeková, Ľubica Lehocká

Čes. slov. farm. 2012, 61(1):40-43  

In our study we dealt with the frequently occurring influenza virus that infects humans regardless of age or sex. The flu is not of importance only in health problems but also in the economic ones, such as the treatment costs and patients' ability to work. We focused particularly on the most effective preventive measure against the virus, which is vaccination and the risk groups that are the most vulnerable ones to the virus. One of the objectives of this research was to identify the advantages and disadvantages of vaccination against influenza and available risks of vaccination within a group of 390 patients. We studied a group of 195 vaccinated patients...

Analytical profile of mono[{3-[4-(2-ethoxyethoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium] fumarate

Ivan Malík, Lenka Mitterová, Fils Andriamainty, Petr Mokrý, Miloš Lukáč, Jozef Csöllei, Jana Gališinová, Janka Karlovská

Čes. slov. farm. 2012, 61(1):44-52  

The present paper aims at a complex spectral and physicochemical evaluation of mono[{3-[4-(2-ethoxyethoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium] fumarate, the potential ultra-short acting blocker of ß₁-adrenergic receptors. The identity of the evaluated compound (labelled as UPB-2) was confirmed by ¹H-, ¹³C-NMR and IR spectral data as well. The estimated physicochemical parameters included melting point data, solubility in various media, purity checking (adsorption thin-layer chromatography), surface activity determination (non--direct Traube stalagmometric method), acidobasic characteristics...

Identification of lipoxygenase expressing ω-6 dioxygenase activity by means of liquid chromatography

Peter Hoffman, Mária Cupáková, Drahomíra Rauová, Renáta Kollárová, Mária Pekárová, Marek Obložinský, Lýdia Bezáková

Čes. slov. farm. 2012, 61(1):53-59  

Lipoxygenases (LOX) represent a family of lipid peroxidising enzymes which catalyse the reaction of achiral polyunsaturated fatty acids by oxygen forming chiral peroxide products possessing high positional stereospecific purity. The four double bonds of arachidonic acid, the main substrate of animal LOX, present the position for a wide range of enzymatic modifications enabling eicosanoid creation, unique molecules with biological significance. In this study, lipoxygenase from rat lung cytoplasma was isolated and purified to 40-fold by combining hydrophobic and gel chromatography. The forming positional specific fatty acid hydroxyl-isomers were separated...

Intended pharmacotherapeutical approaches of Alzheimer's disease therapy

Jan Korábečný, Eva Hrubá, Ondřej Soukup, Filip Zemek, Kamil Musílek, Eugenie Nepovímová, Katarína Špilovská, Veronika Opletalová, Kamil Kuča

Čes. slov. farm. 2012, 61(1):4-10  

Alzheimer's disease is a progressive neurodegenerative disorder mainly manifested by memory loss, personality changes, and cognitive dysfunction. Despite the fact that tireless research is being conducted, up-to-date pharmacotherapy of AD is presented only by two groups diverging in the mechanism of action. The larger one uses acetylcholinesterase inhibitors, and the second group is represented by the N-methyl-D-aspartate antagonist memantine. Even though the etiology of Alzheimer's disease is unknown, several different therapeutic approaches are being investigated. The aim of this paper is to provide an overview of the present state of intended therapeutics...

The possibilities of innovation of extemporaneous preparation in pharmacies in the Czech Republic

Zbyněk Sklenář, Kateřina Horáčková

Čes. slov. farm. 2012, 61(1):11-16  

Extemporaneously prepared products still have an irreplaceable role in therapy. In order to boost the magistral preparation, the availability of appropriate substances for the pharmacies must be ensured. This is due to the fact that many commercial pharmaceutical products containing these active ingredients do not comply with the individual requirements of a particular patient. Based on the practice requirements, the most requested substances have been chosen and within two years 16 pure substances with quality certificates have been provided for magistral preparation in pharmacies, and there are other chemicals coming. The increased availability of...

Derivatives of phenylcarbamic acid as potential antituberculotics

Karel Waisser, Jozef Čižmárik

Čes. slov. farm. 2012, 61(1):17-20  

Basic esters of phenylcarbamic acid were studied by the teams of Prof. Čižmárik and Prof. Waisser as potential antituberculotics. Their antimycobacterial activity increased with lipophilicity. The most active derivatives were substituted with an alkoxy group in position p- on the phenyl. The activity of some of them almost approached that of INH, but they exceeded it only in the evaluation against the INH-resistant strains M. avium and M. kansasii. The carbamates produced by Prof. Vinšová and co-workers published in the last year show that carbamates can be still topical.

Metabolomics in research of phytotherapeutics

Katarína Kráľová, Josef Jampílek, Ivan Ostrovský

Čes. slov. farm. 2012, 61(1):21-25  

Pharmaceutical and food industries are increasingly focused on the great potential of plant secondary metabolites or natural substances which can be used as therapeutics or model compounds for development of new drugs. The paper is devoted to the use of metabolomics, metabolic profiling and metabolic "fingerprint" for the identification of individual active phyto-substances in plant extracts, in profiling of unique groups of plant secondary metabolites that can be used to improve the classification of several species of medicinal plants as well as for a better characterization and quality control of medicinal extracts, tinctures and phytotherapeutic...

Nové knihy

Jozef Čižmárik

Čes. slov. farm. 2012, 61(1):39  

Nové knihy

Jozef Čižmárik

Čes. slov. farm. 2012, 61(1):52  

Pracovní den Sekce technologie léků České farmaceutické společnosti ČLS JEP. Pokroky v lékových formách

Čes. slov. farm. 2012, 61(1):62-68  

Zprávy

Čes. slov. farm. 2012, 61(1):69-73  

40. mezinárodní kongres pro dějiny farmacie

Jan Babica

Čes. slov. farm. 2012, 61(1):74  

Study of local anaesthetics - Part 196. Formulation of the local anaesthetic heptacaine into hydrogel on the basis of chitosan

Jozef Čižmárik, Zuzana Vitková, Petra Herdová

Čes. slov. farm. 2012, 61(1):60-61  

The study aimed to formulate the local anaesthetic heptacaine into hydrogels on the basis of chitosan. The gel-creating compounds used included natural polymers - three different types of chitosan, namely those of a medium molecular weight, from the shells of shrimp, and from the bumblebees species Bombus terrestris. The prepared hydrogels were evaluated on the basis of their rheological properties and drug liberation. From the point of drug liberation and flow properties, the optimal gel composition was as follows: 0.1% heptacaine + 2% chitosan (medium molecular weight) + 0.2% carbaethopendecinium bromide.