JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2012, 61(1):17-20

Derivatives of phenylcarbamic acid as potential antituberculotics

Karel Waisser1,*, Jozef Čižmárik2
1 Farmaceutická fakulta Univerzity Karlovy
2 Katedra farmaceutické chemie, Farmaceutická fakulta, Univerzita Komenského v Bratislavě

Basic esters of phenylcarbamic acid were studied by the teams of Prof. Čižmárik and Prof. Waisser as potential antituberculotics. Their antimycobacterial activity increased with lipophilicity. The most active derivatives were substituted with an alkoxy group in position p- on the phenyl. The activity of some of them almost approached that of INH, but they exceeded it only in the evaluation against the INH-resistant strains M. avium and M. kansasii. The carbamates produced by Prof. Vinšová and co-workers published in the last year show that carbamates can be still topical.

Keywords: antituberculotics; carbamic acid; antimycobacterial activity; tuberculosis; multiresistant mycobacteria

Received: September 26, 2011; Accepted: October 26, 2011; Published: January 1, 2012  Show citation

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Waisser K, Čižmárik J. Derivatives of phenylcarbamic acid as potential antituberculotics. Čes. slov. farm. 2012;61(1-2):17-20.
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