Effects of aluminium chloride on cell growth and production of coumarins in cell suspension cultures of Angelica archangelica L.

T. Siatka, M. Kašparová

Čes. slov. farm. 2010, 59(3):112-116  

Elicitation of plant cells in culture represents a useful biotechnological tool to improve the production of secondary metabolites. In this study, aluminium chloride at various concentrations (1, 10, 50, 100, 500, and 1000 μM) was tested as a potential elicitor of the production of coumarins in angelica cell suspension cultures. In addition, the toxicity of aluminium ions for the culture was assessed by evaluating their effect on cell growth (characterized by fresh and dry biomass at the end of a two-week subculture). Cultures were cultured in the dark or in the light. Fresh biomass was not affected significantly in the presence of aluminium chloride...

Pyrazinecarboxylic acid derivatives as effective abiotic elicitors of isoflavonoids production

L. Tůmová, J. Tůma, M. Doležal, B. Danielová

Čes. slov. farm. 2010, 59(3):117-122  

Genista tinctoria (Dyer's Greenweed) is a plant containing isoflavonoids, which rank among important estrogens. The in vitro culture of this plant produces more isoflavonoids than the parent plant. The paper aimed to even more increase the production of these substances in the callus culture by the action of abiotic elicitors, in this case pyrazinecarboxylic acid derivatives. A more suitable elicitor for the production of isoflavonoids proved to be substance A (N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide), even though the absolute maximum of genistin production was achieved by a 12-hour action of substance B (5-terc-butyl-6-chloro-N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide)...

Influence of the kind of polymer on chlorhexidine liberation from hydrogel

Z. Vitková, M. Žabka, P. Herdová

Čes. slov. farm. 2010, 59(3):123-126  

The aim of this paper was to select the optimal polymer for the formulation of the model drug chlorhexidine dichloride into hydrogel. Two types of biopolymers were used, one of the modified polymers was of herbal origin taken from the group of cellulose derivates - methylcellulose, hydroxyethylcellulose and hydroxypropylcellulose, and the other was of animal origin - chitosan of a medium and a high molecular weight. The polymers were used in a concentration of 2.5% (m/m). Drug liberation was evaluated by the percentage of the drug released into the physiological solution. In addition, the rheological properties of hydrogels were evaluated. Judging...

A comparison of the retardation effects of natural matrix-forming polymers and the synthetic polymers Kollicoat SR and Eudragit NE

B. Vladovičová, V. Kormanová, M. Vítková, Ž. Bezáková, M. Žabka

Čes. slov. farm. 2010, 59(3):127-134  

The formulation of modified-release dosage forms optimizes the pharmacokinetic profile of the drug, reduces the fluctuations of plasmatic concentration, increases the drug benefit and improves the patient's compliance. Modification of the characteristics of the controlled membrane enables to achieve the desired drug release profile. The matrix system and/or the multiple unit dosage form provide a reliable guaranty of the controlled delivery of the drug from the modified-release dosage form. Both above-mentioned formulations were prepared and evaluated in this experimental study. The aim of the study was the preparation of a modified-release dosage...

Analytical methods for the determination of selected psychopharmaceuticals

R. Uřinovská, M. Turjap, H. Brozmanová, M. Grundmann

Čes. slov. farm. 2010, 59(3):103-111  

At present at our disposal there are more than one hundred psychopharmaceuticals with more or less specific effects on the symptoms of individual mental disorders. Despite new therapeutic and diagnostic possibilities there are still many patients whose response to treatment with psychopharmaceuticals is not satisfactory. Introduction of a routine therapeutic monitoring of some psychopharmaceuticals could help to individualize and optimize the treatment according to the needs of a individual patient. This paper describes the analytical methods which enable their determination with regard to antidepressants and antipsychotics. At present the principal...

Neue Arzneimittel - Fakten und Bewertungen von 2005 bis 2007 zugelassenen Arzneimitteln, Band 18.

Čes. slov. farm. 2010, 59(3):150  

XXXII. pracovní dny sekce radiofarmacie České společnosti nukleární medicíny ČLS JEP. Zlín, 9.-11. června 2010

Čes. slov. farm. 2010, 59(3):135-143  

Životné jubileum RNDr. Viery Hermanovej

J. Čižmárik

Čes. slov. farm. 2010, 59(3):147-148  

Vybrané kurzy, stáže a semináře IPVZ - 2. pololetí roku 2010

Čes. slov. farm. 2010, 59(3):148-150  

Z činnosti farmaceutických společností

Čes. slov. farm. 2010, 59(3):144-146