Čes. slov. farm. 2010, 59(3):127-134
A comparison of the retardation effects of natural matrix-forming polymers and the synthetic polymers Kollicoat SR and Eudragit NE
- 1 Zentiva a. s., Hlohovec, Slovenská republika
- 2 Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra galenickej farmácie, Slovenská republika
- 3 Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie, Slovenská republika
The formulation of modified-release dosage forms optimizes the pharmacokinetic profile of the drug, reduces the fluctuations of plasmatic concentration, increases the drug benefit and improves the patient's compliance. Modification of the characteristics of the controlled membrane enables to achieve the desired drug release profile. The matrix system and/or the multiple unit dosage form provide a reliable guaranty of the controlled delivery of the drug from the modified-release dosage form. Both above-mentioned formulations were prepared and evaluated in this experimental study. The aim of the study was the preparation of a modified-release dosage form containing trimetazidine by applying matrix-forming hydrophobic and hydrophilic polymers and their comparison with the synthetic film-forming hydrophobic polymers Eudragit® NE and Kollicoat® SR. Glycerolbehenas as the control release polymer showed a low effect. Drug release was significantly prolonged by natural polymers, and the effect of alginate sodium was more significant in comparison with carrageenan. A reservoir system containing both polymers under study is suitable for the formulation of a CR dosage form.
Keywords: trimetazidine; alginate sodium; carrageenan; Eudragit® NE; Kollicoat® SR
Received: May 18, 2010; Accepted: June 1, 2010; Published: March 1, 2010 Show citation
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