Czech and Slovak Pharmacy, 2007 (vol. 56), issue 3
Original Articles
Variability of the essential oil from three sorts of Echinacea MOENCH genus during ontogenesis
Š. Vaverková, M. Mikulášová, M. Habán, J. Tekeľ, M. Hollá, P. Otepka
Čes. slov. farm. 2007, 56(3):121-124 
The content and quality of the essential oil in relation to the main ontogenetic stages of plants were studied in three various sorts of Echinacea genus. The comparison included Echinacea purpurea, Echinacea atrorubens, and Echinacea pallida. The differences in the content of the oil in different parts of plants and the abundance of individual oil constituents in oils from the sorts under study at the optimum stage of ripeness for harvest were evaluated as well.
Fagopyrum esculentum in vitro
L. Tůmová, M. Píchová, J. Dušek
Čes. slov. farm. 2007, 56(3):125-128
Common buckwheat is a valuable source of the flavonoid rutin. Its in vitro culture was derived from a young seedling plant and the content of flavonoids in the callus culture was compared with their content in an intact plant. The optimal nutrient medium for the cultivation of the in vitro culture and for the production of flavonoids is Murashige and Skoog medium which contains, during the cultivation in the normal light regime, the growth regulators combination of 2,4-D 1 mg/l and kinetin 1 mg/l.
Thermoplastic granulation as an alternative method for the preparation of hydrophiliclipophilic oral matrix tablets
K. Dvořáčková, M. Rabišková, R. Masteiková, L. Vocilková
Čes. slov. farm. 2007, 56(3):129-134
The paper focuses on the formulation of HPMC K-matrix tablets by compression of granulates previously prepared by melt granulation. The model drug was theophylline monohydrate. Montanglycol wax was used as the solid lipid binder in a concentration of 10-20 %. With respect to the obtained results, thermoplastic granulation was found to ensure suitable porosity, flow, and particle size of the granulates. In both dissolution media (phosphate buffer pH 6.8 and artificial gastric juice pH 1.2), the release of the model drug is dependent on the HPMC viscosity grade used. The release rate can be modified by a change in the HPMC-to-montanglycol wax ratio....
Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes mellitus in an experiment (a pilot study)
L. Bartošíková, J. Nečas, T. Bartošík, M. Pavlík, J. Fráňová, G. Kuzmina, J. Luža
Čes. slov. farm. 2007, 56(3):135-140
The antioxidative and antidiabetic effect of pomiferin was monitored under the experimental conditions of alloxan-induced diabetes mellitus. The animals were divided by random selection into 2 groups (n=7). The treated group was administered pomiferin in peroral doses of 10 mg/kg in Avicel, the placebo group was given only a solution of Avicel, and the last group was intact. Selected laboratory parameters (glucose, urea, cholesterol, antioxidative enzymes, total antioxidative capacity, malondialdehyde in serum; diuresis, total glucose and protein losses through urine) were determined. Kidney tissue and pancreas samples were taken for histopathological...
Chitosan in topical preparations
D. Matušová, E. Truplová
Čes. slov. farm. 2007, 56(3):141-145
Within the framework of experimental work at the Department of Pharmaceutical Technology of Slovak Medical University, "insect" chitin obtained from the buff-tailed bumblebee (Bombus terrestris) was processed to produce dosage forms and compared with commercially available chitin, or chitosan, obtained from shrimps (Pandalus borealus). The paper aimed to find whether insect chitin, or chitosan, possessed similar technological properties as commercially available and for topical preparations used products. Samples were prepared containing chitin, or chitosan, of different origin, 0.25 and 0.5 % in a gel base. In some gels the gel base was acidified...
Review articles
HPLC separation of enantiomers using chiral stationary phases
D. Meričko, J. Lehotay, J. Čižmárik
Čes. slov. farm. 2007, 56(3):107-113
During recent few years, separations of enantiomers have become one of the most important analytical tasks. Modern separation techniques, such as the chromatographic ones, represent a very powerful tool in this respect and nowadays they are commercially and widely used all over the world. The importance of enantioseparation must be emphasized, not just because of drugs, food additives, and pesticides, but also because of other compounds which affect our life. The use of direct chromatographic enantioseparation seems to be a suitable approach not just in the analytical but also the preparative scale. This paper is focused on the separation of enantiomers...
Naphthoquinones and their pharmacological properties
P. Babula, V. Adam, L. Havel, R. Kizek
Čes. slov. farm. 2007, 56(3):114-120
Naphthoquinones are wide-spread phenolic compounds in nature. They are products of bacterial and fungal as well as high-plants secondary metabolism. Juglone, lawsone, and plumbagin are the most widespread compounds. Naphthoquinones display very significant pharmacological properties - they are cytotoxic, they have significant antibacterial, antifungal, antiviral, insecticidal, antiinflammatory, and antipyretic properties. Pharmacological effects to cardiovascular and reproductive systems have been demonstrated too. The mechanism of their effect is highly large and complex - they bind to DNA and inhibit the processes of replication, interact with numerous...
History of Pharmacy
Medicinal preparations in a manuscript of a fifteen-century Franciscan monk in Brno
P. Drábek
Čes. slov. farm. 2007, 56(3):146-149
An unknown Franciscan monk, who worked in his monastery's apothecary in Brno at the beginning of the 15th century, translated many extracts from Ancient and medieval authors into Czech. The collection, supplemented perhaps also from other manuscripts, contains a number of articles on treatment. It was repeatedly copied and has been preserved in several variants. The collection lists about two hundred medicinal preparations and many other pieces of advice and recommendations, mainly based on folk wisdom and knowledge. The most frequently listed items are aromatic waters, electuaries, potions, ointments, and plasters. The paper deals primarily with the...