Czech and Slovak Pharmacy, 2006 (vol. 55), issue 5
Original Articles
Studies of the Properties of Tablets Made from Directly Compressible Starch and Its Mixtures with Directly Compressible Lactose
J. Mužíková, E. Moučková
Čes. slov. farm. 2006, 55(5):236-241 
The paper studies the strength and disintegration time of compacts made from directly compressible Starch 1500 and its mixtures with directly compressible lactose Pharmatosa DCL 15 in different relative proportions in dependence on the added lubricant magnesium stearate and the model active ingredient ascorbic acid. The dry binders under study differ in their mechanisms of compression and thus in their sensitivity to the addition of the lubricant, which is manifested in decreased strengths of the compacts as well as the mechanism of disintegration of the compacts. The mixtures of substances under study were in the relative representations of 1:3, 1:1...
Flavonoids - Main Constituents of the Leaves of Holodiscus discolor (Pursh) Maxim.
M. Haladová, E. Eisenreichová, M. Mrižová, D. Grančai, K. Ubik
Čes. slov. farm. 2006, 55(5):242-244
The paper deals with the isolation and identification of constituents of the leaves of Holodiscus discolor (Pursh) Maxim. (Rosaceae). Three flavonoid glycosides of flavonol type were isolated from the methanolic extract: kaempferol-3-O-rhamnoside, quercetin-3-O-glucoside (isoquercitrin) and quercetin-3-O-rhamnoside (quercitrin). Isolates were identified by physical-chemical data, by comparison with authentic samples and literature data. The above-mentioned compounds were isolated from Holodiscus discolor (Pursh) Maxim. for the first time.
Review articles
New Systems for Colonic Drug Targeting
L. Janovská, D. Vetchý, M. Rabišková
Čes. slov. farm. 2006, 55(5):203-209
Colonic drug delivery systems are useful for the treatment of inflammatory bowel diseases (ulcerative colitis, Crohn's disease), some carcinomas, gastrointestinal infections and diseases that are sensitive to circadian rhythms, such as asthma, angina pectoris and arthritis, where an intention time delay in the absorption of the drug is required. The colon region is a site for the entry of peptides, proteins, nucleotides and vaccines into the systemic circulation due to local absence of digestive enzymes. Colonic drug targeting ensures direct treatment at the disease site and a possible reduction in the administered dose. A drug is not absorbed into...
Some Possibilities of Using Spectrometry in the Near Infrared Region in Drug Quality Control
J. Šubert
Čes. slov. farm. 2006, 55(5):210-212
Spectrometry in the near infrared region ranks among the modern methods of analytical chemistry and is of use also in drug quality control. The paper draws attention to some possibilities of using the method in this respect, including its possible use in the check-out of the identity of the content of closed packages of medicinal and auxiliary substances supplied to pharmacies.
Radionuclide X-ray Fluorescence as an Alternative Method to Pharmacopeial Tests for Heavy Metals
V. Jánošová, M. Sýkorová, O. Štroffeková, E. Havránek
Čes. slov. farm. 2006, 55(5):213-218
Pharmacopeial tests for heavy metals require comparisons between test solution's colour after addition of thioacetamide and a control solution containing a known quantity of Pb. As this test neither informs about the type of heavy metals, nor about the concentrations of each of them, there is a reason for more frequent employment of instrumental methods such as AAS and AES, as well as ICP, NAA, and X-ray fluorescence. These methods provide us with quick and exact elemental analyses of impurities, thus becoming more and more important in the quality control of drugs and medicinal plants.
Plant Metabolites as Nootropics and Cognitives
F. Červenka, L. Jahodář
Čes. slov. farm. 2006, 55(5):219-229
Nowadays several millions of people suffer from Alzheimer's disease and other types of dementia. Etiology of these diseases is not known very well. There occur different levels of neurotransmitters, the level of acetylcholine in the brain is decreased and pathological changes affect the brain tissue. Organic and toxic damage of the brain, free radicals, and other changes participate in the development of these diseases. Drugs as nootropics, cognitives, and neuroprotectives are commonly used to treat these diseases. Some of these drugs have often side and undesirable effects. In recent years some natural substances (galanthamine, huperzine A, vinpocetine),...
A Comparison of Inhalatory Beta2-Mimetics with Long-Term Action (Formoterol vs. Salmeterol)
P. Kollár, H. Kotolová
Čes. slov. farm. 2006, 55(5):230-235
Asthma is a serious global health problem. People of all age groups in all countries of the world suffer from this chronic disease of the respiratory tract, which may have a very serious and sometimes fatal course. Most ß2-mimetics with a rapid onset of effect act for 4 to 6 hours. Inhalatory ß2-mimetics with long-term action (LABA), formoterol and salmeterol, possess a period of action longer than 12 hours. Formoterol and salmeterol represent great progress in asthma management, particularly in combination with inhalatory corticosteroids (IKS). Their effective bronchodilatory properties and long-term improvement of pulmonary functions are a great...