JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2006, 55(5):213-218

Radionuclide X-ray Fluorescence as an Alternative Method to Pharmacopeial Tests for Heavy Metals

V. Jánošová, M. Sýkorová, O. Štroffeková, E. Havránek
Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej analýzy a nukleárnej farmácie

Pharmacopeial tests for heavy metals require comparisons between test solution's colour after addition of thioacetamide and a control solution containing a known quantity of Pb. As this test neither informs about the type of heavy metals, nor about the concentrations of each of them, there is a reason for more frequent employment of instrumental methods such as AAS and AES, as well as ICP, NAA, and X-ray fluorescence. These methods provide us with quick and exact elemental analyses of impurities, thus becoming more and more important in the quality control of drugs and medicinal plants.

Keywords: heavy metals; limit tests for heavy metals; AAS; ICP; X-ray fluorescence spectrometry

Received: February 5, 2006; Accepted: June 22, 2006; Published: May 1, 2006  Show citation

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Jánošová V, Sýkorová M, Štroffeková O, Havránek E. Radionuclide X-ray Fluorescence as an Alternative Method to Pharmacopeial Tests for Heavy Metals. Čes. slov. farm. 2006;55(5):213-218.
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