Czech and Slovak Pharmacy, 2005 (vol. 54), issue 6
Original Articles
Composite Tincture from the Tops of the Purple Coneflower (Echinacea purpurea) and the Fruits of the Dog Rose (Rosa canina): Technology of Production and Evaluation of Quality
J. Bernatonienė, A. Savickas, R. Masteiková, Z. Chalupová
Čes. slov. farm. 2005, 54(6):262-265 
This paper aimed to elaborate the technology of the production of a composite tincture with an immunostimulatory and adaptogenic effect, to select suitable methods of quality evaluation, and perform stability tests. The tops of the purple coneflower (Echinaceae herba) and fruits of the dog rose (Cynosbati fructus) in a ratio of 1:1 were employed to prepare the tincture. The tincture itself was prepared in a ratio of 1:5. The experiment revealed that ethanol 50 % was the most suitable extracting agent. The optimal conditions for the obtaining of a quality tincture are formed when the drug is disintegrated into the required degree by grinding, percolation...
Isotachophoretic Determination of Desloratadine in Tablets and Syrup
P. Kubačák, P. Mikuš, I. Valášková, E. Havránek
Čes. slov. farm. 2005, 54(6):266-269
Desloratadine was determined in two dosage forms (tablets and syrup) with the use of the method of capillary isotachophoresis. Several electrolyte systems of varying composition and varying pH were tested. Two electrolyte systems were selected for the validation of the method and determination of desloratadine in real samples. In both electrolyte systems, the precision, correctness, linearity, robustness, and selectivity of the ITP method were evaluated. The pre-treatment of the sample prior to analysis consisted in dissolving and diluting the pertinent desloratadine-containing dosage form with demineralized water to the required concentration. This...
Analytical Profile of 1-(4-Fluorophenyl)-4-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]piperazinium chloride (6f)
E. Sedlárová, I. Malík, J. Csöllei, F. Andriamanty
Čes. slov. farm. 2005, 54(6):270-274
The paper presents the results of an analytical evaluation and a study of some physicochemical properties of a potential antiarrhythmic agent marked as 6f. The melting point, spectral properties, solubility and chromatographic behaviour of the drug on the thin layer were investigated. For the content determination, spectrophotometry in the ultraviolet region of the spectrum at the wavelength of the second absorption maximum of the substance and high-performance liquid chromatography were used.
Review articles
Contemporary Programme of Pharmaceutical Studies in Germany
J. Malý, J. Kolář
Čes. slov. farm. 2005, 54(6):247-250
In the year 2002, both the Czech and Slovak Faculties of Pharmacy celebrated the fiftieth anniversary of the existence of four-year and later five-year university courses of pharmaceutical studies, the contents of which were being continuously modified in order to comply with principal trends in the field of pharmacy. A new programme of pharmaceutical studies which has just started at German universities can serve us as a certain example and provide comparison, or inspiration.
Logistics in the Pharmaceutical Service
P. Stanko, M. Fulmeková
Čes. slov. farm. 2005, 54(6):251-255
The conception of the field of pharmaceutical service defines pharmaceutical service as the basic part of pharmacy, the principal task of which is to provide pharmaceutical care as an inseparable part of providing health care. It represents a set of professional activities of the pharmacist oriented to securing human and veterinary pharmaceutical products and health care products and to optimising effective, safe and quality pharmacotherapy. Technically, pharmaceutical service is an applied discipline, as it makes use of knowledge gained in other pharmaceutical, medical, psychological, social, and economic sciences. Because of its interdisciplinary...
Interconversion of Stereochemically Unstable Chiral Drugs: Utilization of Chromatographic Techniques for the Study of Enantiomerization, Calculation of Thermodynamic Parameters Part I: Theoretical Aspects
A. Fedurcová, J. Lehotay, J. Čižmárik
Čes. slov. farm. 2005, 54(6):256-261
The paper explains the theoretical aspects of the process of enantiomerization and describes its characteristic features (generation of a plateau). In addition, some complications are presented that are produced by enantiomerization either from analytical or pharmacological points of view. It also defines the way of how to calculate energy barriers of enantiomerization according to the methods used for the separation of racemic mixtures (stopped-flow or dynamic chromatography). Mathematic models useful in deconvolution of chromatograms are also described. With the use of dynamic methods it is not possible to quantitatively evaluate the obtained chtromatograms...
History of Pharmacy
Pharmaceutical Literature in the Library of the Kuks Hospice I. A Contribution to the History of the Hospital Pharmacy of the Brethern of Mercy Called "The Pomergranate" at Kuks
J. Drha
Čes. slov. farm. 2005, 54(6):275-282
During the research of the history of the Baroque pharmacy of the Merciful Brethern at the Kuks Hospice (Eastern Bohemia), established in 1743, and its professional standard, pharmaceutical literature was found at the preserved hospice library. The present author first focused on the existence of basic, obligatory literature: dispensatories, tariffs of medicaments, and juridical literature (pharmaceutical laws). There survived a small number of these books because many books were destroyed during various wars. The following dispensatories (pharmacopoeias) were found: Dispensatorium pharmaceuticum Austriaco-Viennense 1729/1738, Dispensatorium Regium...