JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2005, 54(6):270-274

Analytical Profile of 1-(4-Fluorophenyl)-4-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]piperazinium chloride (6f)

E. Sedlárová1, I. Malík1, J. Csöllei2, F. Andriamanty1
1 Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie
2 Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav chemických léčiv

The paper presents the results of an analytical evaluation and a study of some physicochemical properties of a potential antiarrhythmic agent marked as 6f. The melting point, spectral properties, solubility and chromatographic behaviour of the drug on the thin layer were investigated. For the content determination, spectrophotometry in the ultraviolet region of the spectrum at the wavelength of the second absorption maximum of the substance and high-performance liquid chromatography were used.

Keywords: aminopropanoles; antiarrhythmics; Ca2+-antagonists; analytical profile

Received: June 1, 2005; Accepted: July 27, 2005; Published: June 1, 2005  Show citation

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Sedlárová E, Malík I, Csöllei J, Andriamanty F. Analytical Profile of 1-(4-Fluorophenyl)-4-[3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl]piperazinium chloride (6f). Čes. slov. farm. 2005;54(6):270-274.
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