Czech and Slovak Pharmacy, 2002 (vol. 51), issue 6
Articles
Immunosuppressives, Retinoids and New Trends in Psoriasis Therapy
M. Svozil
Čes. slov. farm. 2002, 51(6):267-272
Some psoriasis forms can be successfully treated with topical medicaments; serious and extensiveforms cannot be cured without systemic treatment with retinoids (etretinate, acitretin, tazarotene)or withimmunosuppressives (methotrexate, cyclosporine A, tacrolimus,SDZ 281-240). Immuno-therapyand nucleotide analogues are being newly introduced, a number of potentially effectivesubstances interfering with pathogenetic mechanisms participating in the emergence and self-prolongationof psoriasis are in the stage of research and clinical trials, and gene therapy possibilitiesare being investigated.The development and testing of drugs serving therapy for psoriasis...
What Every Worker in the Synthesis and Analysis of Drugs Could Learn from the Law Concerning Chemical Substances and Chemical Preparations
J. Šubert
Čes. slov. farm. 2002, 51(6):273-276
Commencing with 1 January 2000, law No. 157/98 of the Coll. in the wording of law 352/99 of theColl., government orders No. 25/99 of the Coll., 258/2001 of the collection, and other implementationregulations based on the regulations and directives of the European Community have been validfor the handling of chemical substances and preparations in the Czech Republic. The present paperdiscusses and comments on the parts of the law which are important for the management andrunning of the establishments engaged in the synthesis or analysis of drugs. It further lists examplesof highly toxic chemical substances which can occur at these establishments.
The Scullcap Plant (Scutellaria baicalensis Georgi) - A Potential Resource of New Drugs
J. Martin, J. Dušek
Čes. slov. farm. 2002, 51(6):277-283
The scullcap (Scutellaria baicalensis Georgi) is a medicinal plant of traditional Chinese medicineand the drug - Scutellariae radix - is, because of its antioxidant, antiviral, antibacterial, antiinflammatory,antialergic, and sedative properties, the subject of intensive development. This paperreports the results of pharmacological-toxicological studies of this drug and its flavonids approximatelyfrom the year 1990 till the year 2001. The results confirm the validity of traditional use andat the same time indicate that some flavonoids have more utilizable therapeutic effects. Mainlybaicalein seems to be a prospective medicine for the treatment of some...
Reactive Fractal Dimension of Scopolamine Bromide Release from Hydrogel
Z. Zatloukal
Čes. slov. farm. 2002, 51(6):284-286
First-order release kinetics is characterized by a linear dependence of the release rate on thereleased amount of the active ingredient, the triple of the absolute value of the exponent of theexponential function expressing the reactive fractal dimension DR. Scopolamine bromide releasefrom hydroxypropylmethylcellulose hydrogel was first expressed by first-order kinetics with anestimated DR ranging from 2.98-3.00. The employment of an exponential equation with theexponent of release n renders it possible to make an assumption about the mechanism of release.Within a range of n=0.505-0.550, estimated DR=2.46-2.94. In this region, release by means of themechanism...
Analysis of Current Conservative Treatment of Nephropathies
K. Gazdíková, P. Korecká, V. Špringer, F. Gazdík
Čes. slov. farm. 2002, 51(6):287-291
Treatment by dialyzing represents an important contribution to the therapy of nephropathic patients. On the other hand, besides high financial costs it is not possible to forger significant social and psychic consequences of this therapy. The present paper aimed at a pharmacoeconomic evaluation of the costs of conservative treatment of nephropathic patients. The secondary aim was to compare the costs of conservative treatment in patients with markedly limited renal functions, creatinine clearance (Ccr < 0.4 ml/s), with those in patients with only slightly and medium-reduced renal functions (Ccr 0.4-1 ml/s). Health documentation from three nephrological...
Knowledge of Patients about the OTC Preparation as the Result of Pharmacist - Patient Consultations
B. Macešková
Čes. slov. farm. 2002, 51(6):292-296
Knowledge of patients about oral single-component OTC preparations containing ibuprofen, boughtfor their own use,was evaluated in relation to the manner of the process of communication betweenthe pharmacist (laboratory assistant) - patient during the supply at the pharmacy. The answers ofrespondents were processed separately for the group of those who bought the preparation for thefirst time and those who had already used it for self-medication. The knowledge of contraindicationsand undesirable effects (judged separately) was found to be higher than 50 % in both groups ofrespondents. Nevertheless, the patients who use the preparation repeatedly state...
Anti-yeast Activity of the Ethanolic Extracts of Lilium candidum L.
P. Mučaji, D. Hudecová, M. Haladová, E. Eisenreichová
Čes. slov. farm. 2002, 51(6):297-300
The paper deals with anti-yeast activity of ethanolic extracts from the flowers and bulbs of Liliumcandidum L., Liliaceae, as well as some compounds isolated from these extracts. Several differentmethods were used for the determination of anti-yeast activity: Lowry method of protein determination,dilution and cultivation method. The extract from the bulbs was shown to be more activethan the extract from the flowers, while isolated compounds were inactive against the tested yeasts.
The Construction of a Baculovirus Expression System for in vitro Production of Isoenzymes P4501A1 and P4503A4
M. Šafářová, E. Kvasničková
Čes. slov. farm. 2002, 51(6):301-304
The aim of this work is the construction of an expression system for in vitro synthesis of microsomalmonooxygenases P4501A1 and P4503A4, which catalyze oxidative transformations of most xenobioticsin both animal and human organisms. cDNAs encoding both proteins were obtained followingthe UBMTA protocol by the courtesy of holders, and amplified by established methods. Baculovirustransfer vectors were used to clone these cDNAs. These vectors contain a strong polyhedrinepromoter surrounded by sequences homologous to that of baculovirus DNA, allowing the recombinationof the vector with the viral DNA, and hence the production of a protein. Established methodsand...
Preparation and Physico-Chemical Properties of Alkyl Esters of [(2-Hydroxy 3-diphenyl-methylpiperazinyl)propoxy] Carbanilic Acids
R. Opatřilová, P. Mokrý, J. Csöllei, M. Blešová
Čes. slov. farm. 2002, 51(6):305-309
The paper is devoted to the synthesis and study of some physico-chemical properties of a group ofsubstances - potential antagonists of beta-adrenergic receptors. The substances are derivatives ofaryloxyaminopropanol, where the basic part consists of diphenylmethylpiperazine and the aromaticpart is modified with alkyl esters (methyl to butyl) of carbamic acid in positions 2-, 3-, 4-. Therepresentation of the elements was confirmed by elemental analysis. The substances were characterizedby melting point, IR and UV spectra. Their solubility and surface acitivity were determined.The purity of prepared substances was examined by means of TLC.
Therapy of Hyperhomocysteinemia by Vitamin B12
M. Krajčovičová-Kudláčková, P. Blažíček, K. Šebeková, M. Valachovičová
Čes. slov. farm. 2002, 51(6):310-312
Prevalence of mild hyperhomocysteinemia in vegetarians and vegans is a consequence of vitaminB12 deficiency. Clinical study of homocysteine reduction by vitamin B12 consisted of subjectivehealthy adults on alternative nutrition (n=9) with vitamin B12 deficiency and with mild hyperhomocysteinemia.Vitamin B12 treatment was implemented by 5 intramuscular cyanocobalamininjections of a total content of 2200 µg during two weeks. Homocysteine level was significantlyreduced (from 22 µmol/l to 11.7 µmol/l; individual reduction 29-55 %). Vitamin B12 concentrationin blood was significantly increased (from 152 pmol/l to 277 pmol/l; individual%of...