Čes. slov. farm. 2002, 51(6):310-312

Therapy of Hyperhomocysteinemia by Vitamin B12

M. Krajčovičová-Kudláčková¹, P. Blažíček², K. Šebeková¹, M. Valachovičová¹

¹ Ústav preventívnej a klinickej medicíny, Bratislava

² Nemocnica Ministerstva obrany, Bratislava

Prevalence of mild hyperhomocysteinemia in vegetarians and vegans is a consequence of vitaminB12 deficiency. Clinical study of homocysteine reduction by vitamin B12 consisted of subjectivehealthy adults on alternative nutrition (n=9) with vitamin B12 deficiency and with mild hyperhomocysteinemia.Vitamin B12 treatment was implemented by 5 intramuscular cyanocobalamininjections of a total content of 2200 µg during two weeks. Homocysteine level was significantlyreduced (from 22 µmol/l to 11.7 µmol/l; individual reduction 29-55 %). Vitamin B12 concentrationin blood was significantly increased (from 152 pmol/l to 277 pmol/l; individual%of increase 63-150).The results show a high effect of vitamin B12 treatment in homocysteine value reduction of subjectson alternative nutrition.

Keywords: hyperhomocysteinemia; vegetarians; vegans; vitamin B12

Published: June 1, 2002  Show citation