Czech and Slovak Pharmacy, 2001 (vol. 50), issue 3
Articles
Improvement of Amperometric Detection (AD) by Determination of Drugs by Flow Injection Methods - Flow Injection Analysis (FIA) and Sequential Injection Analysis (SIA)
P. Papugová, M. Poláček
Čes. slov. farm. 2001, 50(3):107-112
The present review dealing with the use of various electrochemical detection systems in flowmethods of analysis of drugs (such as FIA and SIA techniques). The review covers the period of 1988to 1998 and involves 78 references. The drugs determined are arranged according to the functionalgroups undergoing electrochemical transformation; for all the analytes data on the detectionconditions, detection limits and ranges of quantitation are included. Advantages and drawbacks ofamperometric detection of drugs in flow systems are discussed.
Sorbents Used for the Extraction on the Solid Phase and Their Use
M. Gargoš, R. Karlíček
Čes. slov. farm. 2001, 50(3):113-119
Extraction on the solid phase is a rapid, simple, effective, and flexible method of preparation ofsamples for the analysis proper and it can be used in many areas of analysis (pharmacy, biochemistry, food industry, environmental examination, etc.). Possible use in on-line and automatic systemsis also advantageous. A very wide scale of proposed sorbents and the use of their combinations thusmake extraction on the solid phase an effective method for the isolation and preconcentration of theanalyte from the complex matrix of the sample.
Situation of Yemeni Public Health Service and Possible Cooperation with the Czech Republic in the Field of Pharmacy
A. Alwarafi, S. Hartlová
Čes. slov. farm. 2001, 50(3):120-123
The pharmaceutical market in Yemen represents a potential target for Czech pharmaceutical firms.It requires a knowledge of specific conditions of Yemeni health service and pharmacy. With regardto different cultures and languages, Yemeni pharmaceutical market is practically unknown to us.On the basis of an analysis of the materials of the Ministry of Statistics and the Ministry of PublicHealth, the paper presents the data about the growth in the number of inhabitants, the number ofhealthservice establishments, the structure and number of workers in health services, morbidity ofthe population, and a list of typical diseases. The hitherto unpublished...
Effect of n-Decane and n-Octadecane on the Autoperoxidation of Egg Yolk Phosphatidylcholine in Multilamellar Liposomes: Correlation with the Lipid Bilayer Thickness and Bilayer Stability
D. Uhríková, P. Balgavý, J. Filípek
Čes. slov. farm. 2001, 50(3):124-130
Conjugated dienes (CD) and thiobarbituric acid reactive substances (TBARS) have been estimatedduring the autoperoxidation of chromatographically pure phosphatidylcholine from hen eggs(EYPC) in multilamellar liposomes by UV-VIS spectrophotometry. During the propagation phaseof autoperoxidation reaction, n-decane (C10) and n-octadecane (C18) gradually inhibit EYPCperoxidation up to 0:2:1 and 1:1 alkane:EYPC molar ratios, respectively. At higher molar ratios, theyield of estimated autoperoxidation products increases. At the highest molar ratio studied (alkane:EYPC = 2:1), the CD and TBARS concentrations exceed their levels in control sample without alkane...
Use of OTC Preparations Containing Ibuprofen in Self-Medication
B. Macešková
Čes. slov. farm. 2001, 50(3):131-134
Ibuprofen (MO1AE01) is a suitable means for self-medication with regard to its relatively widespectrum of indication, good tolerance, and safety. In the Czech Republic, OTC preparationscontaining ibuprofen represent frequently used medicaments. The paper examines solid divideddosage forms for oral administration. A survey based on questionnaires reveals in what indicationsand according to what dosing schemes the purchased preparations are used, and the paper e valuatespossible risks. Strengthening of the role of the pharmacist as the provider of information on drugs,keeping patients™ drug records in pharmacies, and deepening of the mutual cooperation...
The Opinions and Attitudes of Patients Visiting Pharmacies
J. Kolář, R. Kaleta, J. Gregor
Čes. slov. farm. 2001, 50(3):135-147
The paper is devoted to the problems concerning the opinions and attitudes of customers ofpharmacies, i.e. their opinions on and attitudes to the question of information needs and satisfactionwith information and services provided in pharmacies in the Czech Republic. The article presentsthe results of a questionnaire survey answering the following questions: why the respondents cometo pharmacies and what the reason of the present visit is, whom they prefer as the dispenser of thedrug and why, how often they went to a pharmacy in the recent period, from where they getinformation concerning drugs, whether it is advantageous for them to obtain informat...
Antimycobacterial salicylanilides and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones
K. Waisser, J. Gregor, P. Holý, L. Kubicová, V. Klimešová, J. Kaustová
Čes. slov. farm. 2001, 50(3):148-152
Salicylanilides and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones are strong antimycobacterial substances which can be considered to be potential antituberculotics. In order to be able to verify theprognostics of the relationships between the structure and antimycobacterial activity, the series of previously evaluated substances was extended to include 4'-ethoxycarbonylsalicylanilide, 4'-tri-fluoromethylsalicylanilide, 4'-cyanidosalicylanilide, 4'-thiocarbamoylsalicylanilide, 3-(4-ethoxycar-bonylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dione, 3-(4-trifluoromethylphenyl)-2H-1,3-benzoxazine--2,4(3H)-dione, and 3-(4-cyanidophenyl)-2H-1,3-benzoxazine-2,4-(3H)-dione....
Study of Local Anesthetics. Part 154: Study of Micelization of the Homologs of Heptacainium Chloride
F. Andriamainty, J. Čižmárik
Čes. slov. farm. 2001, 50(3):153-155
We have studied the critical micellar concentration (c.m.c.) of the homologs of the local anestheticheptacaine in the medium 0.1 mol/l NaCl, employing spectrophotometry in the UV region of the spectrum at T=21 °C and pH » 4.5-5.0. On the basis of our experimental results, it is assumed thatin the homologous series of amphiphilic compounds the quasi-parabolic dependence of biologicalpotencies on the length of their hydrophobic substituent (-cut-offit effect) could be caused by c.m.c.