Čes. slov. farm. 2001, 50(3):153-155
Study of Local Anesthetics. Part 154: Study of Micelization of the Homologs of Heptacainium Chloride
- Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
We have studied the critical micellar concentration (c.m.c.) of the homologs of the local anestheticheptacaine in the medium 0.1 mol/l NaCl, employing spectrophotometry in the UV region of the spectrum at T=21 °C and pH » 4.5-5.0. On the basis of our experimental results, it is assumed thatin the homologous series of amphiphilic compounds the quasi-parabolic dependence of biologicalpotencies on the length of their hydrophobic substituent (-cut-offit effect) could be caused by c.m.c.
Keywords: local anesthetic; heptacaine; critical micellar concentration (c.m.c.)
Published: March 1, 2001 Show citation