JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2015, 64(4):139-143 | DOI: 10.36290/csf.2015.030

Influence of Ganoderma lucidum (Curt.: Fr.) P. Karst. on T-cell-mediated immunity in normal and immunosuppressed mice line CBA/Ca

Iryna V. Nizhenkovska1,*, Vitalii T. Pidchenko2, Nina G. Bychkova2, Nina A. Bisko3, Angela Y. Rodnichenko4, Natalya O. Kozyko2
1 Head at Department of Biological, Bioorganic and Pharmaceutical Chemistry of Bogomolets National Medical University, Kyiv, Ukraine
2 Bogomolets National Medical University, Kyiv, Ukraine
3 M.G. Kholodny Institute of Botany NASU, Kyiv, Ukraine
4 The State Institute of Genetic and Regenerative Medicine NAMS Ukraine, Kyiv, Ukraine

The article presents the results of the investigation of the effect of biomass powder of the fungus Ganoderma lucidum on T-cell-mediated immunity in normal and immunosuppressed mice CBA/Ca. Delayed-type hypersensitivity assay was used. Experimental immunodeficiency was established with intraperitoneal injection of the immunosuppressant cyclophosphamide at a single dose of 150 mg/kg on the first day of the experiment. Results of the study show that the administration of biomass powder of Ganoderma lucidum in a dose of 0.5 mg/kg orally for 10 days increases the delayed-type hypersensitivity response in normal mice CBA/Ca. Administration of 0.5 mg/kg of biomass powder of the fungus Ganoderma lucidum for 10 days blocked the development of the T-cell-mediated immunosuppression, induced by administration of cyclophosphamide and restored the delayed-type hypersensitivity response in immunosuppressed mice.

Keywords: fungus Ganoderma lucidum; cyclophosphamide; immunodeficiency; T-cell-mediated immunity; delayed-type hypersensitivity

Received: August 31, 2015; Accepted: September 8, 2015; Published: April 1, 2015  Show citation

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Nizhenkovska IV, Pidchenko VT, Bychkova NG, Bisko NA, Rodnichenko AY, Kozyko NO. Influence of Ganoderma lucidum (Curt.: Fr.) P. Karst. on T-cell-mediated immunity in normal and immunosuppressed mice line CBA/Ca. Čes. slov. farm. 2015;64(4):139-143. doi: 10.36290/csf.2015.030.
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