JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2014, 63(6):248-252 | DOI: 10.36290/csf.2014.047

An overview of urease and its relation to the ureolytic bacteria and the search for new urease inhibitors

Petra Hřibová*, Elian Khazneh
University of Veterinary and Pharmaceutical Sciences Brno, Department of Natural Drugs, Faculty of Pharmacy, Brno

In this review, an overview of the available literature on urease is presented. Urease is an enzyme which catalyzes the hydrolysis of urea. The occurrence of ureases and their functions are discussed thoroughly. The relationship of urease to ureolytic bacteria is examined, and the currently available urease inhibitors, both inorganic and natural, are presented. Finally, the importance of urease and current and future applications of new inhibitors and explored.

Keywords: bacteria; inhibitor; urease
Grants and funding:

Financial support for this work was obtained from the Internal Grant Agency (IGA), VFU, Brno, grant number: 89/2012/FaF.

Received: December 5, 2014; Accepted: December 15, 2014; Published: June 1, 2014  Show citation

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Hřibová P, Khazneh E. An overview of urease and its relation to the ureolytic bacteria and the search for new urease inhibitors. Čes. slov. farm. 2014;63(6):248-252. doi: 10.36290/csf.2014.047.
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