Clinical trials in the European Union and the Czech Republic in the years 2006, 2009 and 2012

Juraj Šesták, Věra Strnadová

Čes. slov. farm. 2014, 63(6):253-262 | DOI: 10.36290/csf.2014.048  

The aim of this paper is to analyze clinical trials conducted in the European Union and the Czech Republic in the years 2006, 2009 and 2012. The analysis has two main points of interest: characterization of the study population (the attention is paid to the age and gender profile of the subjects' population as well as to the fact whether healthy volunteers and/or patients were enrolled) and clinical trials focus (the phases of clinical trials and therapeutic areas the trials were focused on). In addition, the aim of this paper is to discover possible differences between the EU and the CR and to find out if the implementation of Directive 2001/20/EC...

Examples of off-label use of human medicinal preparations in veterinary medicine

Jozef Kolář, Pavel Brauner, Tereza Tichová

Čes. slov. farm. 2014, 63(6):263-266 | DOI: 10.36290/csf.2014.049  

The paper presents several examples of the use of human medicinal preparations (MP) in veterinary medicine, aiming to compare the indications listed in the summary of product characteristics (SmPC) and the indications in which these MPs are used by veterinarians. For the sake of illustration, two human MPs were selected, which, on the basis of a preceding analysis, were found to be those most widely used in veterinary medicine. A questionnaire survey was employed to find information on the indications in which human MPs are prescribed by veterinarians. The set consisted of 200 veterinary surgeries specializing mainly in small animals. The returnability...

Influence of excipients on caffeine permeation from gels

Alexandra Kodadová, Zuzana Vitková, Petra Herdová, Jozef Čižmárik, Monika Zsidová

Čes. slov. farm. 2014, 63(6):267-271 | DOI: 10.36290/csf.2014.050  

The subject of this paper is a study of the influence of excipients on caffeine permeation from dermal semisolids drugs. Due to its advantageous properties, caffeine can be successfully used in dermal hydrogels. The choice of excipients from the group of humectants and cationic surfactants also plays an important role. The excipients should ensure long-term stability of hydrogels and the best permeation of the drug from gels. In particular, the influence of various excipients on caffeine permeation from gels and at the same time their influence on rheological properties of hydrogels were investigated. Based on the obtained results, the following optimal...

Nanoparticulates with drug release based on temperature change

Miloslava Rabišková, Eva Koziolová, Johana Jirásková

Čes. slov. farm. 2014, 63(6):239-247 | DOI: 10.36290/csf.2014.046  

The stimuli-induced release systems are able to respond to an external stimulus resulting in drug release in a controlled pattern. The origin of the external stimuli may be of physical, chemical or biological nature. Thermo-responsive delivery systems respond to the change in temperature and they were mainly designed in order to be used in the cancer treatment method using elevated temperature, i.e. hyperthermia. The thermo-responsive systems can be divided into several groups, such as thermo-responsive hydrogel polymer systems, liposomes, nano- or microparticles, and polypeptide-drug conjugates. While liposomes are temperature-sensitive by their nature,...

An overview of urease and its relation to the ureolytic bacteria and the search for new urease inhibitors

Petra Hřibová, Elian Khazneh

Čes. slov. farm. 2014, 63(6):248-252 | DOI: 10.36290/csf.2014.047  

In this review, an overview of the available literature on urease is presented. Urease is an enzyme which catalyzes the hydrolysis of urea. The occurrence of ureases and their functions are discussed thoroughly. The relationship of urease to ureolytic bacteria is examined, and the currently available urease inhibitors, both inorganic and natural, are presented. Finally, the importance of urease and current and future applications of new inhibitors and explored.

Doc. RNDr. Milan Řehula, CSc. ^*4. ledna 1950 - ^†27. listopadu 2014

M. Rabišková

Čes. slov. farm. 2014, 63(6):273  

Výsledky voleb do výboru a sekcí České farmaceutické společnosti ČLS JEP pro období 2015-2018

Čes. slov. farm. 2014, 63(6):272  

Autorský rejstřík

Čes. slov. farm. 2014, 63(6):276-278  

Věcný rejstřík

Čes. slov. farm. 2014, 63(6):279-280