JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2012, 61(5):203-209

Bergenia genus - content matters and biological activity

Helena Hendrychová*, Lenka Tůmová
Farmaceutická fakulta UK, Katedra farmakognozie, Hradec Králové

Bergenia, a genus included in the family Saxifragaceae, is a valuable source of healing matters. About 30 Bergenia species are known all over the world. Scientific research is focused on five species mainly distributed in the mountains of Central and East Asia: Bergenia ciliata (Haw.) Sternb., Bergenia stracheyi Engl., Bergenia crassifolia (L.) Fritsch, Bergenia ligulata (Wall.) Engl. and Bergenia himalaica Boriss. These taxons belong to the widely used medicinal herbs in the traditional Chinese, Nepalese and Indian medicine, for therapy of cough and pulmonary diseases, to stop bleeding, to increase immunity and to dissolve kidney or bladder stones. Bergenia consists of many different active compounds including bergenin, norbergenin, catechin, gallic acid, arbutin and other polyphenols. In the Czech Republic this species is commonly grown but it is not used for medical therapy. Individual parts of this plant demonstrate an interesting biological activity, and antibacterial, antiviral, cytoprotective and antioxidant effects.

Keywords: Bergenia; biological activity; arbutin; bergenin
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Práce byla podpořena Specifickým vysokoškolským výzkumem SVV 265 004.

Received: June 15, 2012; Accepted: August 16, 2012; Published: May 1, 2012  Show citation

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Hendrychová H, Tůmová L. Bergenia genus - content matters and biological activity. Čes. slov. farm. 2012;61(5):203-209.
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    References

    1. Yongsi Z., Changmin L., Xiaohong L., Jun L., Shoumin F., Yunxiang L., Daowen H. Biological advances in Bergenia genus plant. Afr. J. Biotechnol. 2011; 10, 8166-8169. Go to original source...
    2. Zhang Y. S., Liao C. M., Liu X. H., Li J., Fang S. M., Li X. Y., He D. W. Biological advances in Bergenia genus plant. Afr. J. Biotechnol. 2011; 10, 8166-8169. Go to original source...
    3. Butola J. S., Badola H. K. Threatened Himalayan medicinal plants and their conservation in Himachal Pradesh. J. Trop. Med. Plants 2008; 9, 125-142.
    4. Chowdhary S., Kumar H., Verma D. L. Biodiversity and traditional knowledge of Bergenia spp. in Kumaun Himalaya. N. Y. Sci. J. 2009; 2, 105-108.
    5. Ruby K. M., Dwivedi J., Chauhan R. Pashanbheda a golden herb of Himalaya: a rewiev. I. J. Pharm. Res. 2012; 2, 97-105.
    6. Khare C. D. (ed.). Indian medicinal plants, an ilustrated dictionary. Springer 2007; 90-91. Go to original source...
    7. Kubát K., Hrouda L., Chrtek J., Kaplan Z., Kirschner J., Štěpánek J. (Eds.). Klíč ke květeně České republiky. Praha: Academia 2002; s. 308.
    8. Rai L. K., Prasad P., Sharma E. Conservation threats to some important medicinal plants of the Sikkim Himalaya. Biol. Cons. 2000; 93, 27-33. Go to original source...
    9. Kaul M. K. Medicinal plants of Kashmir and Ladakh. New Delhi: M. L. Gidwani 1997; 179.
    10. Chowdhary S., Verma K. R. Some peculiar structures in Bergenia species growing in Western Himalaya. Nat. Sci. 2010; 8, 1-4.
    11. Patel D. K., Patel K., Kumar R., Gadewar M., Tahilyani V. Pharmacological and analytical aspects of bergenin: a concise report. Asian Pac. J. Trop. Biomed. 2011; 1-5. Go to original source...
    12. Hack-Seang K., Hwa-Kyung L., Myeon-Woo Ch., Young Ch. K. Antihepatotoxic activity of bergenin, the major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated hepatocytes. J. Ethnopharm. 2000; 69, 79-83. Go to original source... Go to PubMed...
    13. Reddy U. D. C., Chawla A. S., Deepak M., Singh D., Handa S. S. High pressure liquid chromatographic determination of bergenin and (+)-afzelechin from different parts of Paashaanbhed (Bergenia ligulata Yeo). Phytochem. Anal. 1999; 10, 44-47. Go to original source...
    14. Pop C., Vlase L., Tamas M. Natural resources containing arbutin, determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania. Notulae Botanicae Hort. Agrobot. 2009; 37, 129-132.
    15. Singh D. P., Srivastava S. K., Govindarajan R., Rawat A. K. S. High-performance liquid chromatographic determination of bergenin in different Bergenia species. Acta chromat. 2007; 19, 246-252.
    16. Umashankar D. Ch., Amrik S. Ch., Deepak M., Rakesh M., Sukhdev S. H. Paashaanolactone from Bergenia ligulata. Phytochemistry 1997; 47, 907-909. Go to original source...
    17. Bruce A. B., Donevan L. S., Bhat U. G. Flavonoids of some species of Bergenia, Francoa, Parnassia and Lepuropetalon. Biochem. Syst. Ecol. 2002; 14,75-77. Go to original source...
    18. Pozharitskaya O. N., Ivanova S. A., Shikov A. N., Makarov V. G., Galambosi B. Separation and evaluation of free radical-scavenging activity of phenol components of green, brown, and black leaves of Bergenia crassifolia by using HPTLC-DPPH method. J. Sep. Sci. 2007; 30, 2447-2451. Go to original source... Go to PubMed...
    19. Rajbhandari M., Mentel R., Jha P. K., Chaudhary R. P., Bhattarai S., Gewali M. B., Karmacharya N., Hipper M., Lindequist U. Antiviral activity of some plants used in Nepalese traditional medicine. Evid-based Compl. Altern. Med. 2009; 6, 517-522. Go to original source... Go to PubMed...
    20. Nighat N., Surrinder K., Mushtag A. Q., Muzaffar H. N., Mohammed I. Z. Evaluation of antioxidant and antimicrobial activities of bergenin and its derivatives obtained by chemoenzymatic synthesis. European J. Med. Chem. 2011; 46, 2415-2420. Go to original source... Go to PubMed...
    21. Rajkumar V., Guha G., Kumar R. A., Lazar M. Evaluation of antioxidant activities of Bergenia ciliata rhizome. Records Nat. Prod. 2010; 4, 38-48.
    22. Sinha S., Murugesan T., Maiti K., Gayen J. R., Pal M., Saha B. P. Evaluation of anti-inflammatory potential of Bergenia ciliata Sternb. rhizome extract in rats. J. Pharm. Pharmacol. 2001; 53, 193-196. Go to original source... Go to PubMed...
    23. Kakub G., Gulfraz M. Cytoprotective effects of Bergenia ciliata extract on gastric ulcer in rats. Phyto. Research. 2007; 21, 1217-1220. Go to original source... Go to PubMed...
    24. Pant S., Samant S. S., Arya S. C. Diversity and indigenous household remedies of the inhabitants surrounfing Mornaula reserve forest in West Himalaya. I. J. T. K. 2009; 08, 606-610.
    25. Uniyal S. K., Singh K. N., Jamwal P., Lal B. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya. J. Ethnobiol. Ethnomed. 2006; 2, 14. Go to original source... Go to PubMed...
    26. Sajad T., Zargar A., Ahmad T., Bader B. N., Naime M., Ali S. Antibacterial and anti-inflammatory potential Bergenia ligulata. Am. J. Biomed. Sci. 2010; 2, 313-321. Go to original source...
    27. Hussain Z., Waheed A., Qureshi R. A., Burdi D. K., Verspohl E. J., Khan N., Hasan M. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phyto. Research. 2004; 18, 73-77. Go to original source... Go to PubMed...
    28. Bhandari M. R., Nilubon J. A., Hung G., Kawabata J. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata Haw.). Food Chem. 2007; 106, 247-252. Go to original source...
    29. Joshi V. S., Parekh B. B., Joshi M. J., Vaidya D. B. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol. Res. 2005; 33, 80-86. Go to original source... Go to PubMed...
    30. Vimal S. J., Bharat B. P., Mihir J. J., Ashok D. B. V. Inhibition of the growth of urinary calcium hydrogen phospate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol. Research. 2005; 33, 80-86. Go to original source... Go to PubMed...
    31. Kartik Ch. P., Surendra K. P., Ranjit K. H., K. Jayaram K. Traditional approaches towards standardization of herbal medicines - a review. J. Pharm. Sci. Technol. 2010; 2, 372-379.
    32. Li S., Lu A., Wang Y. Symptomatic comparison in efficacy on patients with benign prostatic hyperplasia treated with two therapeutic approaches. Compl. Therap. Med. 2010; 18, 21-27. Go to original source... Go to PubMed...
    33. Zheng X., Zheng L., Xie Y., Cai X., Wang Y., LV R. Pharmacokinetics of bergenin in rabbits. J. Yunnan Univ. 2011; 33, 206-209. Go to original source...
    34. Shi Y. B., Shi Y. P., Meng Q. G. Determination and pharmacokinetic study of bergenin in rat plasma by RP-HPLC method. Biomed. Chromatogr. 2006; 20, 1065-1070. Go to original source... Go to PubMed...
    35. Qin X., Zhou D., Zhang Z., Huang Y. The absorbtion kinetics of bergenin in intestines of rat. West China J. Pharm. Sci. 2007; 22, 186-188.
    36. Yu W., Wang Y., Zhang Y., Zhang D., Lan J., Gu J., Fawcett J. P. Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spektrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Sci. 2009; 877, 199-203. Go to original source... Go to PubMed...
    37. Wang J., Wang B., Wei Ch., Yuan G., Zhang R., Liu H., Zhang X., Guo R. Determination of bergenin in human plasma after oral administration by HPLC-MS/MS method and its pharmacokinetic study. Biomed. Chromatogr. 2009; 23, 199-203. Go to original source... Go to PubMed...
    38. Dušková J., Dušek J., Jahodář L. Bergenia crassifolia (L.) Fritsch in vitro. Čes. slov. Farm. 2001; 2, 83-85.
    39. Novak J. Arbutin - a risk substance in herbs? Zeits. Arz. Gewurzpflanzen. 2010; 15, 170-173.
    40. Chowdhary S., Kumar H., Verma D. L. Chemical examination of Bergenia stracheyi (Hk.) for antioxidative flavonoids. Nat. Sci. 2009; 7, 29-34.
    41. Uddin G., Rauf A., Arfan M., Ali M., Qaisar M., Saadiq M., Atif M. Preliminary phytochemical screening and antioxidant activity of Bergenia ciliata. Middle-East J. Sci. Res. 2012; 11, 1140-1142.
    42. Venkatadri R., Guha G., Rangasamy A. K. Evaluation of antioxidant activities of Bergenia ciliata rhizome. Rec. Nat. Prod. 2010; 4, 38-48.
    43. Ivanov S. A., Nomura K., Malfanov I. L., Sklyar I. V., Ptitsyn L. R. Isolation of a novel catechin from Bergenia rhizomes that has pronounced lipase-inhibiting and antioxidative properties. Fitoterapia 2011; 82, 212-218. Go to original source... Go to PubMed...
    44. Shikov A. N., Pozharitskaya O. N., Makarova M. N., Dorman H. J. D., Makarov V. G., Hiltunen R., Galambosi B. Adaptogenic efect of black and fermented leaves of Bergenia crassifolia L. in mice. J. Funct. Foods. 2010; 2, 71-76. Go to original source...
    45. Shah M. R., Arfan M., Amin H., Hussain Z., Qadir M., Choudhary M.m, VanDerveer D., Mesaik M. A., Soomro S., Jabeen A., Khan I. U. Synthesis of new bergenin derivates as potent inhibitors of inflammatory mediators NO and TNF-alpha. Bioorg. Med. Chem. Lett. 2012; 22, 2744-2747. Go to original source... Go to PubMed...
    46. Yoshida T., Seno K., Takama Y., Okuda T. Bergenin derivates from Mallotus japonicus. Phytochem. 2001; 21, 1180-1182. Go to original source...
    47. Atchuta R. P., Row L. R., Reddy D. S., Anjaneyulu A. S. R., Ward R. S., Pelter A. Isolation and characterisation of bergenin derivates from Macaranga peltata. J. Chem. Soc. 1979; 1, 2313-2316. Go to original source...
    48. Wang D., Zhu H. T., Zhang Y. J., Yang Ch. R. A carbon-carbon-coupled dimeric bergenin derivate biotransformed by Pleurotus ostreatus. Bioorg. Med. Chem. Lett. 2005; 15, 4073-4075. Go to original source... Go to PubMed...
    49. Mazhar U. I., Iqbal A., Farah M., Khan U., Muhammad A. G., Afzal A., Shahab U. D. Evaluation of antibacterial activity of Bergenia ciliata. Pakistan J. Pharm. Sci. 2002; 15, 21-27.
    50. Sharad S., Ajay Kumar S. R. Botanical and phytochemical comparison of three Bergenia species. J. Sci. Ind. Res. 2007; 67, 65-72.
    51. Rajbhandari M., Wegner U., Schöpke T., Lindequist U., Mentel R. Inhibitory effect of Bergenia ligulata on influenza virus A. Pharmazie 2003; 58, 268-271.
    52. Popov S. V., Popova G. Y., Nikolaeva S. Y., Golovchenko V. V., Ovodova R. G. Immunostimulating activity of pectic polysaccharide from Bergenia crassifolia (L.) Fritsch. Phyto. Research 2005; 19, 1052-1056. Go to original source... Go to PubMed...
    53. Golovchenko V. V., Bushneva O. A., Ovodova R. G., Shaskov A. S., Chizhov A. O., Ovodov Y. S. Structural study of bergenan, a pectin from Bergenia crassifolia. Rus. Ac. Sci. 2006; 33, 47-56. Go to original source... Go to PubMed...
    54. Churin A. A., Masnaya N. V., Sherstoboev E. Y., Suslov N. I. Effect of Bergenia crassifolia extract on specific immune response parameters under extremal conditions. Acad. Med. Sci. 2005; 68, 51-54.
    55. Sharad S., Ajay Kumar S. R. Simultaneous determination of bergenin and gallic acid in different Bergenia species. J. Plan. Chrom. 2007; 20, 275-277. Go to original source...
    56. Chauhan S. K., Singh B., Agrawal S. Simultaneous determination of bergenin and gallic acid in Bergenia ligulata Wall. by high performance thin-layer chromatography. J. Aoac. Int. 2000; 1480-1483. Go to original source...
    57. Lubsandorzhieva P. B., Zhinghitov B. S., Dargaeva T. D., Bazarova Zh. G., Nagaslaeva L. A. Chromatospectrophotometric determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. Khimiko-Farmats. Z. 2000; 34, 38-40. Go to original source...
    58. Dharmender R., Madhavi T., Reena A., Sheetal A. Simultaneous quantification of bergenin, (+)-catechin, gallicin and gallic acid, and quantification of β-sitosterol using HPLC from Bergenia ciliata (Haw.) Sternb. forma ligulata Yeo (Pasanbheda). Pharm. Anal. Acta 2010; 1, 104. Go to original source...
    59. Hasan A., Hussain A., Khan M. A. Flavonol glycosides from leaves of Bergenia himalaica. Asian. J. Chem. 2005; 17, 822-828.
    60. Saijyo J., Suzuki Y., Okuno Y., Yamaki H., Suzuki T., Miyazawa M. αα-glucosidase inhibitor from Bergenia ligulata. J. Oleo Sci. 2008; 57, 431-435. Go to original source... Go to PubMed...
    61. Nighat N., Surrinder K., Mushtag A. Q., Sachin C. T., Sheikh F. A., Sarang B., Ghulam N. Q. Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis-A flow cytometric study. J. Ethnopharm. 2007; 112, 401-405. Go to original source... Go to PubMed...
    62. Uher J. Bergénie - trvalky stinných zahrad. Zahradnictví 2011; 5, 38-41.

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