JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2009, 58(5):216-224

Influence of formulation technology on theophylline release from chitosan-based pellets

K. Dvořáčková, G. Škrabáková, M. Rabišková*
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků

Pellets containing theophylline, microcrystalline cellulose and chitosan were prepared by wetting with chitosan solution (1-5%) in 10% acetic acid using the extrusion/ spheronization method. The influence of chitosan content (0.98-4.47 %) on theophylline release from pellets was studied and their dissolution profiles were compared with the results obtained in pellets without chitosan and pellets containing 25% of chitosan prepared by wetting with acetic acid. A slower theophylline release (up to 5 hrs) at pH 6.8 from pellets prepared with chitosan solution was found; it was caused probably by the interaction of the carbonyl groups of MCC and the amino groups of chitosan forming a polyionic complex. A prolonged release of the drug was maintained also at pH 1.2, when chitosan dissolves. For the interaction with MCC and prolonged drug liberation it was necessary to use chitosan in the form of a solution.

Keywords: chitosan; microcrystalline cellulose; theophylline; pellets; extrusion, spheronization

Received: October 27, 2009; Accepted: November 11, 2009; Published: May 1, 2009  Show citation

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Dvořáčková K, Škrabáková G, Rabišková M. Influence of formulation technology on theophylline release from chitosan-based pellets. Čes. slov. farm. 2009;58(5-6):216-224.
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