Čes. slov. farm. 2008, 57(4):160-164

Synthesis, identification and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers

S. Kečkéšová^1,*, E. Sedlárová¹, J. Csöllei², P. Mokrý²

¹ Comenius University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bratislava

² University of Veterinary and Sciences Pharmaceutical, Faculty of Pharmacy Institute of Chemical Drugs, Brno

The paper deals with the synthesis, structure confirmation, and study of physicochemical properties of some aryloxyaminopropanol derivatives, compounds of 2-hydroxy-3-[4-(2-fluorophenyl)-piperazine-1-yl]-propyl-4-[(alkoxycarbonyl)amino]benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group. Their structure was confirmed by elemental analysis, IR, UV and mass spectra. The melting point, solubility, surface activity, dissociation constant, and some lipophilicity parameters, i.e. partition coefficient P, RM values from reversed phase thin-layer chromatography, and retention factor k obtained from HPLC of the substances under study were determined.

Keywords: ultrashort-acting beta-blockers; synthesis; physicochemical properties

Grants and funding:

This study was supported by the Comenius University grant No. UK/2/2008.

Received: June 2, 2024; Accepted: June 27, 2024; Published: April 1, 2008  Show citation