JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2007, 56(6):284-287

Evaluation of mechanical strength of tablets from microcrystalline cellulose by means of energetic parameters

M. Řehula
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie

The paper aims to describe a new method for the evaluation of mechanical strength of tablets. The classic pharmacopoeial method of measurement of strength of tablets examines the strength at which the tablet breaks, the found strength being expressed in N. The proposed method of measurement of tablet strength is based on the strength-course record, determined during the process of crushing. This method determines not only the crushing force (DS) in N and the radial strength (RP) in MPa calculated from it, but also other parameters, such as the course of crushing d in mm, the rate constant of crushing process in kNmm-1, the deformation energy DE in mJ, and the volume deformation energy ODE in MJ.m-3. The new parameters are illustrated on tablets from the microcrystalline cellulose Avicel PH 102.

Keywords: kinetics of tablet crushing; strength-course record; course of crushing d; rate constant of crushing k; deformation energy DE; volume deformation energy ODE

Received: October 9, 2007; Accepted: October 30, 2007; Published: June 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Řehula M. Evaluation of mechanical strength of tablets from microcrystalline cellulose by means of energetic parameters. Čes. slov. farm. 2007;56(6):284-287.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Český lékopis 2005. Praha, Grada Publishing a.s., 2005.
    2. Nystrom, Ch., Alex, W., Malmquist, K.: Acta Pharm. Suecica, 1977; 14, 317-320.
    3. Rudnick, A., Hunter, A. R., Holden, F. C.: Mater. Res. Stand., 1963; 3, 283-291.
    4. Fell, J. T., Newton, J. M.: J. Pharm. Sci., 1970; 59, 688-691. Go to original source... Go to PubMed...
    5. Bělousov, V. A.: Chim. Pharm. Ž., 1976; 10, 105-111. Go to original source...
    6. Mrňák, L., Drdla, A.: Mechanika, pružnost a pevnost. Praha, SNTL, 1978, 51-58.
    7. Larhrib, H., Wells, J. I.: Inter. J. Pharm., 1997; 159, 75-83. Go to original source...
    8. de Blaey, C. J., Polderman, J.: Pharm. Weekbl., 1970; 241, 105-109.
    9. Řehula, M., Lavická, J., Musilová, M.: Čes. slov. Farm., 2004; 50, 35-37.

    Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.