JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2007, 56(4):190-199

The effect of polymeric dispersion type on the release of diclofenac sodium from coated pellets

K. Krejčová1, M. Rabišková1, D. Vetchý1, V. Tomášek2, A. Prokopová2
1 Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků
2 Zentiva, a. s. Praha

Recently, coated pellets have gained attention of the pharmaceutical industry as they represent a relatively easy way leading to controlled drug release. Pellets of appropriate properties containing approx. 40 % of diclofenac sodium were prepared by roto-agglomeration. For the coating, two different aqueous dispersions (Surelease® and Eudragit®RS 30 D) were selected. Generally, the drug release rate slowed down as the coating load increased from 10 to 22 %. However, big differences between diclofenac sodium release from pellets coated with Surelease® and Eudragit®RS30D at equivalent coating loads were observed. Although Eudragit®RS 30 D provided membranes successfully controlling drug release over an extended period of 24 hours, the coating process with Surelease® led to a film of a very poor quality. Faster release from ethyl cellulose coated pellets could be explained in terms of a higher solubility of diclofenac sodium in alkaline aqueous dispersion of ethyl cellulose and its migration into the coat during the coating process and/or the unsatisfactory curing of the ethyl cellulose film. Therefore possible interactions between the coating and the drug should be always considered as suggested in this study.

Keywords: coated pellets; diclofenac sodium; Surelease®; Eudragit® RS 30 D

Received: May 27, 2007; Accepted: June 28, 2007; Published: April 1, 2007  Show citation

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Krejčová K, Rabišková M, Vetchý D, Tomášek V, Prokopová A. The effect of polymeric dispersion type on the release of diclofenac sodium from coated pellets. Čes. slov. farm. 2007;56(4):190-199.
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