Čes. slov. farm. 2006, 55(3):120-123

Study of a Newly Synthesized Substance with a Potential to Stimulate ß₃-Adrenergic Receptors

J. Krčmář¹, H. Kotolová¹, L. Veselá¹, J. Csöllei², T. Goněc², M. Karpíšek¹, L. Bartošová¹, J. Nečas¹

¹ Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav humánní farmakologie a toxikologie

² Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav chemických léčiv

ß₃-adrenoreceptor agonists can stimulate lipolysis in the white adipose tissue and thermogenesis in the brown adipose tissue. These activities could be useful in the treatment of obesity and the associated metabolic syndrome. The effects of six-week oral administration of the newly synthesized substance B496 (methyl-4-[2-[2-hydroxy-3-(4-ethylcarbamoyl)phenoxyprophyl]amino]etyl)-phenoxyacetate hydrochloride) on serum glucose, triglycerides, total cholesterol, and leptin levels were studied in male Wistar rats fed with a high-fat diet. The animals were divided into a group treated with B496 (5 mg dissolved in 1 litre of water) and a control group. The results indicated a significant reduction in serum glucose levels (-26 %, p

Keywords: ß₃-adrenoreceptor agonist; aryloxypropanolamines; leptin; BRL-37344

Received: January 11, 2006; Accepted: March 20, 2006; Published: March 1, 2006  Show citation