Čes. slov. farm. 2005, 54(1):23-28
Adsorption of Substances on Active Charcoal Part 2: Basic Esters of Phenylcarbamic Acid with Beta-adrenolytic Effect
- 1 Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
- 2 Ústav chemických léčiv Farmaceutickej fakulty Veterinárnej a farmaceutickej Univerzity, Brno
The paper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyl)oxy]aminopropanol with the identical, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Freundlich and Langmuir models. Affinity of substances of Group A to adsorption material decreases with increasing hydrophilicity.
Keywords: adsorption on active charcoal; esters of phenylcarbamic acid; beta-adrenolytic agents; QSAR
Received: October 31, 2003; Accepted: January 30, 2004; Published: January 1, 2005 Show citation
References
- Bachratá, M., Csöllei, J., Ble‰ová, M. et al.: âes. slov. Farm., 1987; 36, 162-167.
- Mokr˘, P., Csöllei, J., Raãanská, E. et al: Sborník pfiíspûvkÛ 30. Konference syntéza a anal˘za léãiv. Brno, 2001, s. 87.
- Mokr˘, P., Csöllei, J., Raãanská, E. et al.: Sborník pfiíspûvkÛ 54. Sjezdu chemick˘ch spoleãností. Brno, 2002. Chem. Listy, 2002; 96, 397-422, 407.
- Abe, I., Kamaya, H., Ueda, I.: J. Pharm. Sci., 1988; 77, 166-168.
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Go to PubMed... - Roivas, L., Neuvonen, P. J.: Meth. Find. Exp. Clin. Pharmacol., 1994; 16, 367-372.