JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(4):159-167

Therapeutic Drug Monitoring of Cyclosporine A

I. Komzáková1,3, K. Šafarčík2,3, H. Brozmanová1, M. Grundmann1,3
1 Ústav klinické farmakologie FNsP a Zdravotně sociální fakulta Ostravské Univerzity, Ostrava
2 Klinika nukleární medicíny FNsP, Ostrava-Poruba
3 Farmakologický ústav lékařské fakulty Univerzity Palackého, Olomouc

Cyclosporine A (CyA)is a drug with a specific influence on the immune system and it is used bothto prevent tissue rejection of transplanted organs and to treat autoimmune diseases.The properties,metabolism,and methods of therapeutic drug monitoring (TDM)in patients under immunosuppres-sive therapy are described.TDM of CyA reflects the clinical condition of the patient duringimmunosuppression and may include pharmacokinetic and pharmacodynamic data obtained eitherfrom measuring CyA levels in blood,or from determining some other parameters,which aremodulated by CyA (II-2).Although TDM is mainly based on analyzing trough levels of CyA,thedetermination of the whole biological exposition calculated as AUC enables better correlation withthe clinical state of patients.Pharmacodynamic parameters have not been measured routinely yet.

Keywords: cyclosporine A; CyA metabolites; TDM; trough level; AUC

Published: April 1, 2002  Show citation

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Komzáková I, Šafarčík K, Brozmanová H, Grundmann M. Therapeutic Drug Monitoring of Cyclosporine A. Čes. slov. farm. 2002;51(4):159-167.
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