JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(3):140-144

Antimycobacterial Effects of Pyrrolidinoethylesters of Alkoxysubstituted Phenylcarbamic Acids

K. Waisser, J. Čižmárik, K. Dražková, J. Kaustová
Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Katedra farmaceutické chemie Farmaceutické fakulty Univerzity Komenského, Bratislava
Krajská hygienická stanice, Ostrava

Pyrrolidinoethylesters of alkoxysubstituted phenylcarbamic acids, formerly investigated for local anaesthetic activity, can be considered to be potential antituberculotics. They are effective in nitro against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their effect increases with the length of the alkyl chain in the alkoxy group bound to the phenyl. The influence of the position of the alkoxyl chain on the phenyl is not too marked, but it seems to decrease in the series m-, p-, o-.

Keywords: esters of phenylcarbamic acid; mycobacterium; antituberculotics; tuberculostatics; QSAR

Published: March 1, 2002  Show citation

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Waisser K, Čižmárik J, Dražková K, Kaustová J. Antimycobacterial Effects of Pyrrolidinoethylesters of Alkoxysubstituted Phenylcarbamic Acids. Čes. slov. farm. 2002;51(3):140-144.
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