JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2001, 50(6):286-289

A Study of the Anticomplementary Activity of Mahonia aquifolium Crude Extract, Bisbenzylisoquinoline Alkaloids, and Berberine

D. Koą»álová, M. Bukovský, H. Koąčová, A. Kardoąová
Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava
Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Univezita Komenského
Chemický ústav SAV, Bratislava

Crude extracts obtained from the stem bark of Mahonia aquifolium have been investigated as to the chemical composition and anticomplementary activity. The results show that their anticomplementary activity is mainly due to the alkaloid components. Especially the BBI alkaloid fraction and berberine showed a strong inhibitory effect on CH50 total hemolytic complement assay. The crude extract of M. aquifolium was less active than berberine or the fraction BBI alkaloids. The resultsindicate that the fraction of BBI alkaloids and berberine largely account for the immunomodulatory activity of the crude extract of M. aquifolium.

Keywords: Mahonia aquifolium; anticomplementary activity; berberine; fraction BBIalkaloids; crude extract

Published: June 1, 2001  Show citation

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Koą»álová D, Bukovský M, Koąčová H, Kardoąová A. A Study of the Anticomplementary Activity of Mahonia aquifolium Crude Extract, Bisbenzylisoquinoline Alkaloids, and Berberine. Čes. slov. farm. 2001;50(6):286-289.
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