JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2001, 50(4):166-172

Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics

T. Rojkovičová, J. Lehotay, J. Čižmárik
Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

The present review paper describes the properties of the macrocyclic antibiotics vancomycin,teikoplanin, and ristocetin A, which can be used as stationary phases for separation of theenantiomers of drugs containing a stereogenic centre. It analyzes the results obtained in theseparation of amino acids, its derivatives, loxiglumide, clenbuterol, practolol, carnitine, levodopa,methyldopa, ceftazidine, alkoxyphenylcarbamic acid derivatives, dichloroprop, ketoprofen, warfarin, and ergot alkaloids by means of high-performance liquid chromatography (HPLC)

Keywords: vancomycin; teikoplanin; ristocetin A; stationary phases; properties; separation of enantiomers; HPLC

Published: April 1, 2001  Show citation

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Rojkovičová T, Lehotay J, Čižmárik J. Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics. Čes. slov. farm. 2001;50(4):166-172.
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