Čes. slov. farm. 2001, 50(2):70-77
Viral Liver Diseases. Current Status of Therapy
- Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno
Viral liver diseases, particularly hepatitides of type B (HBV) and C (HCV) show an increasing trend,the number of infected people in the world being several hundred million people. With the exceptionof other forms (HAV, HDV, HEV, and HGV), where infectivity is also high, possible transmissionand infection in HBV and HCV are often independent of the affected person (blood transfusion,stomatological operations, surgery, etc.). Treatment of hepatitides not proceeding into a chronicstage is without any problems at the moment. In the case of HBV, besides chemical drugs whichare being developed, vaccination is available. Hepatitis C remains to be a problem of worldimportance. Its growth in recent years runs parallel to an increase in drug addicts and HIV infection.The difficulties in the development of vaccines are related to rapid mutation of the virus andcontinuous formation of other serotypes. Progress in many biological disciplines is a certainwarranty that the so-called NS3 proteases inhibitors and medicaments of other types, includingvaccines, will be introduced into practice for HCV treatment.
Keywords: hepatitis; drugs; treatment
Published: February 1, 2001 Show citation