Čes. slov. farm. 2001, 50(1):38-40

Prednicarbat and Cetirizin Dihydrochloride in the Treatment of Acute Stage of Atopic Eczema in Children

L. Bartošíková¹, L. Fráňa², J. Nečas¹, P. Fráňa³, J. Dzúrová⁴, J. Petrželková¹, P. Kollár¹

¹ Ústav humánní farmakologie a toxikologie Farmaceutické fakulty Veterinární a farmaceutické Univerzity, Brno

² Alergologická a imunologická ambulance - Dům zdraví, Velké Meziříčí

³ I. interní klinika Fakultní nemocnice U sv. Anny, Brno

II. dětská interní klin

The aim of the study was to monitor the impact of local application of prednicarbat (Dermatop,Hoechst-Biotika) and oral administration of cetirizin (Zyrtec, UCB) on the development of the acute stage of atopic eczema (AE) or acute exacerbation of the chronic form of AE in two groups of patients. Effectiveness and safety of both preparations were being evaluated in 80 children undergoing anoutpatient treatment. In the first group, only prednicarbat cream was applied to affected places twice a day for a maximum of 10 days, while in the other group also cetirizin was administered once a day in a dosage according to the patient's age. On the treated places, erythema, infiltrate and excoriation were evaluated with respect to the intensity of manifestation. The results of the study show favourable effects of both preparations on AE development, already during the first days ofthe therapy. In both groups there was a complete remission of the monitored symptoms in more than 80 per cent of the patients. There was no deterioration of the disease in any patient, and no cases of adverse reactions were registered.

Keywords: prednicarbat; cetirizin dihydrochloride; atopic eczema

Published: January 1, 2001  Show citation