JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2018, 67(4):154-159 | DOI: 10.36290/csf.2018.022

Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension

Iryna Nizhenkovska, Kateryna Sedko*, Olena Kuznetsova
Department of Pharmaceutical, Biological and Toxicological Chemistry of Bogomolets National Medical University, Kyiv, Ukraine

Arterial hypertension is a leader among the most common chronic cardiovascular diseases which covers 30-45% of world population with a dynamics of further growth. 1,3-oxazole-4-yl-phosphonic acid derivative (abbreviated as oxazole derivative) is a novel original compound with vasodilating activity. The purpose of this work was to study the NO-mediated mechanism of vasodilating effect of this derivative according to the activity of eNOS, iNOS and NO2- through their content in rats on a resistant arterial hypertension model. The oxazole derivative intraperitoneally administered at a dose of 25 mg/kg prevented development of arterial hypertension by promotion of recovery of eNOS, iNOS and NO2- activity in the studied aorta, heart, and blood serum to the normal level recorded in intact animals. It can be concluded that the mechanism of antihypertensive action of the oxazole derivative is mediated by the NO system.

Keywords: arterial hypertension; nitric oxide; 1,3-oxazole-4-yl-phosphonic acid derivative

Received: June 8, 2018; Accepted: August 6, 2018; Published: April 1, 2018  Show citation

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Nizhenkovska I, Sedko K, Kuznetsova O. Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension. Čes. slov. farm. 2018;67(4):154-159. doi: 10.36290/csf.2018.022.
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