Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension

Iryna Nizhenkovska, Kateryna Sedko, Olena Kuznetsova

Čes. slov. farm. 2018, 67(4):154-159 | DOI: 10.36290/csf.2018.022  

Arterial hypertension is a leader among the most common chronic cardiovascular diseases which covers 30-45% of world population with a dynamics of further growth. 1,3-oxazole-4-yl-phosphonic acid derivative (abbreviated as oxazole derivative) is a novel original compound with vasodilating activity. The purpose of this work was to study the NO-mediated mechanism of vasodilating effect of this derivative according to the activity of eNOS, iNOS and NO₂^- through their content in rats on a resistant arterial hypertension model. The oxazole derivative intraperitoneally administered at a dose of 25 mg/kg prevented development of arterial...

Biological role of copper as an essential trace element in the human organism

Miroslava Pavelková, Jakub Vysloužil, Kateřina Kubová, David Vetchý

Čes. slov. farm. 2018, 67(4):143-153 | DOI: 10.36290/csf.2018.021  

This paper presents an overview of the physiological properties of copper (Cu), an essential trace element playing an important role in the human metabolism, primarily as a cofactor of many metalloenzymes. The maintenance of Cu homeostasis is required for proper functioning of the human body. However, when the disturbance of Cu homeostasis occurs, strong pathological manifestations may develop. Wilson's disease and idiopathic toxicosis are examples of severe chronic liver diseases that are the results of genetic predisposition to the hepatic accumulation of copper. Conversely, congenital Menkes disease is manifested as serious Cu's nutritional deficiency....

PRACOVNÍ DEN SEKCE TECHNOLOGIE LÉKŮ S NÁZVEM "Pokroky ve farmaceutické technologii"

Čes. slov. farm. 2018, 67(4):164-171  

Gas chromatography-mass spectrometry study of the root and herb of Smallanthus sonchifolius

Olga V. Demeshko, Elena V. Krivoruchko, Victoria A. Samoilova, Svetlana V. Romanova

Čes. slov. farm. 2018, 67(4):160-163 | DOI: 10.36290/csf.2018.023  

Smallanthus sonchifolius (yacon) is a new prospective plant cultivated in Europe as a natural sugarcane substitute. It is used for diabetes and for the prevention of obesity. The study of carboxylic acids in the roots and herb of S. sonchifolius was carried out for the first time by gas chromatography-mass spectrometry (GC-MS). As a result of the study, 12 components were found in the roots of S. sonchifolius, 9 of which were carboxylic acids. The S. sonchifolius herb contained 41 components, 18 of which were carboxylic acids. The dominant compounds in the roots were: undecanoic acid, methyl ester - 546.04 mg/kg; 1-benzazirene-1-carboxylic...