JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2011, 60(4):171-181

Antagonists of angiotensin AT1 receptors

Pavol Ježko*, Milan Remko
Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie

The medicinal agents which block AT1 receptors are used for the treatment of hypertension, cardiac failure, and renal diseases. In clinical practice they have been available already for 15 years. All antagonists of AT1 receptors were projected without any knowledge of the space (3D) structure of the AT1 receptor. At present several strategies of projecting antihypertensive drugs are used, which are based on the influence on a number of receptors (e.g. the endothelial ones), not only angiotensin AT1 receptors. With the use of rational methods of drug projecting based on the knowledge of the spatial structure of the active site of the AT1 receptor, a development of new highly effective ligands for the therapy of cardiovascular diseases will be made possible. In the future, a development of drugs can be expected, which will block not only the angiotensin AT1 receptors, but which will be able to influence also other endogenous ligands, e.g. endothelin and nitric oxide.

Keywords: RAAS; AT1 receptors; antagonists of AT1 receptors

Received: May 10, 2011; Accepted: June 24, 2011; Published: April 1, 2011  Show citation

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Ježko P, Remko M. Antagonists of angiotensin AT1 receptors. Čes. slov. farm. 2011;60(4):171-181.
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