JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2004, 53(2):93-95

The in vitro Reactivation of O-Isopropylmethylfluorophosphonate - Inhibited Acetylcholinesteraseby Bisquaternary Oxime HS-6

K. Kuča, J. Cabal
Katedra toxikologie Vojenské lékařské akademie Jana Evangelisty Purkyně, Hradec Králové

The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2--oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerveagent sarin [O-isopropylmethylfluorophosphonate] was evaluated. The reactivators 2-PAM [2-hydroxyiminomethyl-1-methylpyridinium chloride], toxogonin [1,3-bis(4-hydroxyiminomethylpyridinium)-2-oxa-propane dichloride] and H-oxime HI-6 [1-(2-hydroxyiminomethylpyridinium)--3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] were chosen for comparison. The oxime HS-6was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, butit is better than 2-PAM and obidoxime.

Keywords: acetylcholinesterase; sarin; HS-6; HI-6; obidoxime; 2-PAM; in vitro

Published: February 1, 2004  Show citation

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Kuča K, Cabal J. The in vitro Reactivation of O-Isopropylmethylfluorophosphonate - Inhibited Acetylcholinesteraseby Bisquaternary Oxime HS-6. Čes. slov. farm. 2004;53(2):93-95.
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