JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(5):244-247

The Role of the Moistening Agent in the Process of Extrusion and Spheronization

M. Rabišková, J. P. Pérez
Ústav technologie léků Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno

The pellet is an important oral dosage form, interesting because of its numerous technological andpharmacotherapeutic advantages. Extrusion/spheronization is one of the most frequently employedtechnologies of pellet manufacture. Similarly as other technologies, also this process of manufactureinfluences a number of manufacturing and formulating parameters, which are then reflected in thefinal properties of produced pellets. The present experimental paper is concerned with the role ofthe moistening agent in the process of extrusion/spheronization and the examination of its effect onthe size, density, shape, and mechanical and flow properties of pellets.

Keywords: pellets; extrusion, spheronization; amount of the moistening agent; properties of pellets

Published: May 1, 2002  Show citation

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Rabišková M, Pérez JP. The Role of the Moistening Agent in the Process of Extrusion and Spheronization. Čes. slov. farm. 2002;51(5):244-247.
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