Čes. slov. farm. 2000, 49(6):306-312
Studies of Local Anaesthetics, Part 153: The Relationship Between the Chemical Structure, Physical-Chemical Properties, and Biological Activity in a Series of Piperidinopro-pylesters of Alkoxysubstituted Phenylcarbamic Acids
- Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Physical-chemical parameters (surface tension, dissociation constant, RF and RM values determined by means of TLC, logarithm of the capacity factor by means of HPLC) of 30 compounds from the group of piperidinopropylesters of o-, m-, p-alkoxyphenylcarbamic acids with local-anaesthetic activity were determined. The correlation chemical structure - physical-chemical properties - local-anaesthetic activity was studied by means of QSAR. The results of the study have demonstrated a linear dependence between log k, RM, and the number of C in the alkoxysubstituent.
Keywords: piperidinopropylesters of alkoxyphenylcarbamic acids; correlation structure; physical-chemical properties; biological activities
Published: June 1, 2000 Show citation
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Sedlárová E, Čižmárik J. Studies of Local Anaesthetics, Part 153: The Relationship Between the Chemical Structure, Physical-Chemical Properties, and Biological Activity in a Series of Piperidinopro-pylesters of Alkoxysubstituted Phenylcarbamic Acids. Čes. slov. farm. 2000;49(6):306-312.