Czech and Slovak Pharmacy, 2000 (vol. 49), issue 6
Articles
Advances in the Development of New Antituberculotic Agents in the Group of Monocyclic Six-Membered Heterocyclic Compounds with a Larger Number of Nitrogen Atoms
K. Waisser, P. Holý, O. Bureš
Čes. slov. farm. 2000, 49(6):268-277
Tuberculosis and other mycobacterial diseases are considered to be one of the major health problems at present. Since 1985, and in particular in the 1990s, a search for new structures of antimycobacterial substances has been one of the priorities of chemotherapeutic research. Pyrazine derivatives have always attracted the interest of research laboratories searching for new chemotherapeuticagents against tuberculosis. The present review paper, based on the journal Chemical Abstracts and original papers, surveys the attempts of the laboratories searching for new antituberculotic agents in the region of six-membered heterocyclic pyrimidine, pyrazine,...
Chalcones and Their Heterocyclic Analogues as Potential Therapeutic Agents of Bacterial Diseases
V. Opletalová
Čes. slov. farm. 2000, 49(6):278-284
Chalcones and their heterocyclic analogues possess a number of biological effects. Their antifungal effects were reported in the previous communication (Opletalová V., Šedivý D.: Čes. a Slov. Farm.48, 252 (1999)). The present review is devoted to the antibacterial activity of these compounds. For antibacterial activity, the presence of the enone aggregate in the molecule is important. Hydroge-nated analogues are less effective or ineffective, saturated brominated analogues are effective probably after a metabolic transformation into unsaturated a-bromochalcone. In the rings, substitution with a hydroxyl is advantageous, in some cases also substitution...
Allergic Contact Dermatitis Due to Propolis
L. Tůmová, D. Pašavová
Čes. slov. farm. 2000, 49(6):285-287
The present paper describes several individual cases of contact dermatitis in patients using propolisas a component of various cosmetic products, listing the most frequently sensitizing constituents ofpropolis. It also reports the existence of a cross-reaction between the components of Peruvian balsamand propolis constituents.
Kojic Acid and Its Derivatives as Potential Drugs
M. Uher, M. Chalabala, J. Čižmárik
Čes. slov. farm. 2000, 49(6):288-298
The review paper studies kojic acid, a secondary metabolite of fibrous fungi, as a carrier chemical structure of potential pharmaceuticals. The examined preparative procedures, physico-chemical andbiologic properties, and especially the antifungal and antileukemic effects of the parent kojic acid indicate that novel potential drugs can be developed on its basis.
Examination of the Consumption of Hypolipidemic Agents by Means of the Databases of Health Insurance Companies
J. Vlček, K. Macek, H. Müllerová, L. Štika, M. Kočová, H. Hrabětová, Z. Vitásek
Čes. slov. farm. 2000, 49(6):299-305
Databases of health insurance companies can provide information on the motion of a drug in the society. The present paper examines several databases of health insurance companies and analyzesthe development of the consumption of hypolipidemic agents in 1994 through 1998. So-called evaluation databases making it impossible to identify a particular patient and the prescribing physician were prepared for the evaluation. They were obtained from the VZP central health insurance office, VZP district health insurance offices in Hradec Králové and Kladno, and the Zaměstnanecká pojišťovna Škoda (Employees Health Insurance Company Škoda). It was not necessary...
Studies of Local Anaesthetics, Part 153: The Relationship Between the Chemical Structure, Physical-Chemical Properties, and Biological Activity in a Series of Piperidinopro-pylesters of Alkoxysubstituted Phenylcarbamic Acids
E. Sedlárová, J. Čižmárik
Čes. slov. farm. 2000, 49(6):306-312
Physical-chemical parameters (surface tension, dissociation constant, RF and RM values determined by means of TLC, logarithm of the capacity factor by means of HPLC) of 30 compounds from the group of piperidinopropylesters of o-, m-, p-alkoxyphenylcarbamic acids with local-anaesthetic activity were determined. The correlation chemical structure - physical-chemical properties - local-anaesthetic activity was studied by means of QSAR. The results of the study have demonstrated a linear dependence between log k, RM, and the number of C in the alkoxysubstituent.