K 55. výročí založení Farmaceutické fakulty UK v Hradci Králové

doc. PharmDr. Jaroslav Roh, Ph.D.

Čes. slov. farm. 2024, 73(4):211

Pharmacotherapy of chronic heart failure - essential summary for pharmacists

Zdeněk Monhart

Čes. slov. farm. 2024, 73(4):216-221 | DOI: 10.36290/csf.2024.039

Heart failure is a severe and life-threatening condition with significant morbidity and mortality, a reduction in functional capacity and quality of life, and, importantly, heart failure is a substantial social and economic burden. The latest significant advances in therapy have established the recommended pharmacotherapy for patients with heart failure with reduced left ventricular systolic function with fourkey medication classes in each patient: renin-angiotensin-aldosterone system inhibitors (ACE inhibitors, sartans, or sacubitril/valsartan), SGLT2 inhibitors (gliflozins), beta-blockers, and mineralocorticoid receptor antagonists, with diuretics...

Management of gastrointestinal side effects of cancer pharmacotherapy: Part 1: Diarrhoea, constipation, mucositis and anorexia

Jan Juřica, Miroslav Turjap

Čes. slov. farm. 2024, 73(4):222-227 | DOI: 10.36290/csf.2024.040

Gastrointestinal side effects are common in cancer pharmacotherapy and may be facilitated by the disease itself. These adverse effects lead to reduced quality of life and may result in premature termination of therapy, which can adversely affect treatment outcomes. In extreme cases, adverse effects can even lead to patient death. This article reviews the main gastrointestinal side effects of anticancer drug therapy anticancer drug therapy in the context of solid tumor treatment and discusses the appropriate management and discusses the appropriate management of these complications. In the first part of this two-part article, we discuss diarrhoea, constipation,...

Contamination of drugs with nitrosamines, a restored problem

Martin Doležal, Petr Kastner

Čes. slov. farm. 2024, 73(4):228-232 | DOI: 10.36290/csf.2024.041

This review article deals with the issue of nitrosamines as impurities in pharmaceuticals. Medicinal products contaminated with nitrosamine raise legitimate concerns about the safety of medicinal use. Nitrosamines are known to be carcinogens and mutagens. This applies not only to valsartan and all tetrazole-containing angiotensin II receptor blockers, but also to ranitidine, nizatidine, pioglitazone, metformin, rifampicin, rifabutin, varenicline and other drugs, some of which have already been withdrawn from clinical practice. The detection of impurities above the limit in pharmaceutical substances then leads to interruptions in production and shortages...

Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007–2019

Kateřina Malá-Ládová, Helena Šťastná Koblihová, Eva Zimčíková, Anna Oleárová, Ria Benko, Maria Matuz, Reka Viola, Katarina Gvozdanovic, Pero Draganic, Irina Iaru, Josef Malý

Čes. slov. farm. 2024, 73(4):E1-E8 | DOI: 10.36290/csf.2024.036

Introduction and Aim: Due to the growing incidence of thromboembolic disease and atrial fibrillation, increasing trends in anticoagulants consumption can be expected. The aim of this study was to analyse the consumption of anticoagulants in the Czech Republic, Croatia, Hungary, Romania, and Slovakia between 2007 and 2019. Methods: A retrospective analysis of anticoagulants comprising B01AA, B01AB, B01AE, B01AF and B01AX was performed using ATC/DDD methodology. The analysis was initiated in the year before the launch of the first non-vitamin K oral anticoagulant (NOAC). The consumption of each drug was assessed based on annual data and was expressed...

Evaluation tools used for assessing inhalation technique in patients with chronic obstructive lung disease - a literature review

Gabriela Strnadová, Tereza Hendrychová, Vladimír Koblížek, Vratislav Sedlák, Josef Malý

Čes. slov. farm. 2024, 73(4):234-244 | DOI: 10.36290/csf.2024.042

Introduction and aim: Chronic obstructive lung diseases, including bronchial asthma and chronic obstructive pulmonary disease, among others, are characterized by inadequate adherence to inhalation technique. Evaluation of inhalation technique and subsequent repeated patient's education should be a routine part of therapy management. The aim of this article was to provide an overview of tools used to assess inhalation technique in patients with chronic obstructive lung disease based on a literature search and to analyse in more detail individual questionnaires/checklists specific for a group of inhalers or for a particular type of inhaler. Methods:...

Evaluation tools used for assessing inhalation technique in patients with chronic obstructive lung disease - a literature review

Gabriela Strnadová, Tereza Hendrychová, Vladimír Koblížek, Vratislav Sedlák, Josef Malý

Čes. slov. farm. 2024, 73(4):E9-E33 | DOI: 10.36290/csf.2024.037

Introduction and aim: Chronic obstructive lung diseases, including bronchial asthma and chronic obstructive pulmonary disease, among others, are characterized by inadequate adherence to inhalation technique. Evaluation of inhalation technique and subsequent repeated patient's education should be a routine part of therapy management. The aim of this article was to provide an overview of tools used to assess inhalation technique in patients with chronic obstructive lung disease based on a literature search and to analyse in more detail individual questionnaires/checklists specific for a group of inhalers or for a particular type of inhaler. Methods:...

Adjunctive treatment of behavioral disorders in patients with cognitive deficit

Ivana Tašková

Čes. slov. farm. 2024, 73(4):245-250 | DOI: 10.36290/csf.2024.043

The article provides an overview of the pharmacotherapy of behavioural and psychological symptoms of dementia (BPSD) in the context of evidence-based medicine. Its goal is to provide readers with a practical and educational overview of managing these symptoms. Cognitive disorders, including dementia, result from the disruption of higher cortical functions of the brain. Dementia often manifests not only through cognitive dysfunction but also through BPSD, such as agitation, aggression, anxiety, psychosis, and sleep disturbances. These symptoms affect up to 97% of patients with dementia and significantly reduce the quality of life for both patients and...

Pharmaceutical care for patients with sore throat not requiring medical attention

Lenka Ťupová, Tereza Hendrychová, Josef Malý

Čes. slov. farm. 2024, 73(4):252-260 | DOI: 10.36290/csf.2024.044

Counsultancy in self-treatment of mild health problems is one of the dominant aspects of providing pharmaceutical care, especially in pharmacy practice. A sore throat is one of the most common reasons for visiting a pharmacy. According to current knowledge, the biggest pitfall of sore throat management is the systematic and reliable classification of patients into uncomplicated and potentially complicated cases, which should ideally take place at the level of pre-medical care, i.e. in a pharmacy. For this purpose, the practical use of the self-treatment algorithm in the therapy of sore throat was presented in the article. The introduction of a systematic...

Medical devices in wound healing V: Special types of wound plasters II

Barbora Vraníková, Andrej Kováčik

Čes. slov. farm. 2024, 73(4):261-264 | DOI: 10.36290/csf.2024.045

Patches represent a broad category of medical devices with versatile applications that go far beyond their traditional function as wound dressings. This article focuses on the other possible utilization of patches, such as fixation patches for cannulas, patches for epicutaneous tests, warming and cooling patches, patches for acne, anti-snoring patches, and mosquito-repellent patches. In addition to their specific functions, the article highlights the importance of correct application, which represents crucial knowledge not only for pharmacists and pharmacy assistants but also for other healthcare professionals who work with these patches in practice.

Pharmaceutical literature in the Broumov Benedictine convent library in the year 1801

Barbora Machová

Čes. slov. farm. 2024, 73(4):E34-E38 | DOI: 10.36290/csf.2024.038

The article describes composition of the medical collection in the Broumov Benedictine convent library based on a catalogue from the year 1801, with detailed description of titles on pharmacy and botanics. This is followed by comparison with contemporary content of the "Medici" library department, identification of previous book owners and users based on records on preserved books, and an attempt to find out how the monastery communicated with its secular surroundings in the field of pharmacy.

XXVIII. mezinárodní sympozium o medicinální chemii se letos konalo v Římě; 52. mezinárodní konference Syntéza a analýza léčiv se vydařila

prof. PharmDr. Martin Doležal, Ph.D.

Čes. slov. farm. 2024, 73(4):265

Objev nových účinných látek v extraktech z Ginkgo biloba?

MUDr. Andrea Skálová

Čes. slov. farm. 2024, 73(4):268-270

Význam vitaminu C v prevenci poruch nervového a imunitního systému

Pavel Kostiuk, Lucie Kotlářová, Zdeněk Procházka

Čes. slov. farm. 2024, 73(4):271-275