Česká a slovenská farmacie, časopis pro všechny farmaceuty

Výbor České farmaceutické společnosti

Čes. slov. farm. 2024, 73(1):3  

Obsolete for many years but still in use - consumption of phenobarbital in compounding pharmacies

Miroslav Turjap, Eva Pailová, Jan Juřica

Čes. slov. farm. 2024, 73(1):8-12 | DOI: 10.36290/csf.2024.001  

Phenobarbital was synthesized by the German organic chemist Emil Fischer in 1911. It is approved and marketed in the Czech Republic as an antiepileptic in tablet and injection form. Although phenobarbital as a hypnosedative has been outdated for decades, it is still available as a substance and used for the individual compounding of various obsolete mixtures. It is likely that prescribers are unaware of the risks associated with their use. The article presents a brief pharmacological profile of phenobarbital, lists the most often used mixtures, substance consumption and risks associated with its use.

Chronic spontaneous urticaria, treatment with antihistamines

Iva Karlová

Čes. slov. farm. 2024, 73(1):13-15 | DOI: 10.36290/csf.2024.002  

Chronic spontaneous urticaria is characterized by reccurent wheals lasting more than 6 weeks, it can persist for months or years. The disease can lead to a significant worsening in the quality of life. According to recent guidelines second-generation non-sedative antihistamines are the first-line treatment. If the therapeutic effect of the standard dose of antihistamines is insufficient, it is recommended to up-dose to 4-fold.

Pharmacological profile of erdosteine - known molecule - new effects

Hana Kotolová, Martina Nováková

Čes. slov. farm. 2024, 73(1):16-20 | DOI: 10.36290/csf.2024.003  

Erdostein belongs to the well-known thiol mucoactive drugs, whose effect is used in respiratory infections. Recently, expert findings show that the effect of erdosteine is more complex and can significantly contribute to the management of respiratory infections. Its antioxidant and anti-inflammatory properties come to the fore, or antiviral properties associated with them, as well as the ability to reduce bacterial adhesion and increase the effects of some antibiotics. Erdostein represents a comprehensive therapeutic option both in the field of self-treatment of respiratory infections and in other respiratory diseases.

Direct oral anticoagulants from the perspective of Czech pharmacists - opinions, attitudes, confidence, and patient education during dispensing in a pharmacy

Simona Dvořáčková, Kateřina Malá-Ládová, Tereza Mertová, Eliška Kolmanová, Josef Malý

Čes. slov. farm. 2024, 73(1):22-26 | DOI: 10.36290/csf.2024.004  

Introduction and Aim: Pharmacists play an important role in the management of anticoagulation therapy, therefore good knowledge and confidence in care of patients treated with anticoagulation are essential. The aim of this study was to analyse the opinions and attitudes of pharmacists in the Czech Republic towards direct oral anticoagulants (DOACs), their perception of the benefits and risks of DOACs, and the position of pharmacists in educating patients about the basic principles of DOAC treatment in the context of dispensing these medicines in pharmacies. Methods: An online anonymous questionnaire survey conducted in 2021 among pharmacists of three...

Safety of injectable dosage forms during their preparation and administration by nurses in hospitals: a literature review

Ondřej Tesař, Lucie Malečová, Klára Kubíková, Josef Malý

Čes. slov. farm. 2024, 73(1):27-32 | DOI: 10.36290/csf.2024.005  

Introduction and Aim: Medication errors in hospitals are still frequent and significant for patient safety and associated healthcare costs. Especially, injectable dosage forms pose the high risk. The aim of this study was to review the current literature focused on medication errors related to injectable drug forms during their preparation and administration by nurses in hospitals. Methods: Databases Medline and Scopus were used for the literature review. Papers dealing with intravenous (i. v.), intramuscular (i. m.), or subcutaneous (s. c.) administration by nurses in hospitals using direct observation method for data collection were searched. Original...

Oral supplementation of sodium, potassium and phosphate ions in extemporaneous preparation

Markéta Petrželová, Jana Hénková

Čes. slov. farm. 2024, 73(1):33-38 | DOI: 10.36290/csf.2024.006  

The article deals with the possibilities of oral supplementation of three selected ions - sodium, potassium and phosphate, by means of individually prepared medicines. It forms an overview of the most frequently used extemporaneous prescriptions in the University Hospital in Motol. It deals with the description of available raw materials and theoretical characteristics of ions. For selected formulations, the amount of ions is given in both mass and molar terms. The formulas reflect the need for ion supplementation in appropriate doses and appropriate dosage form according to the individual needs of patients.

New edition of the Czech Pharmacopoeia 2023 and what preceded it

Hana Bízková

Čes. slov. farm. 2024, 73(1):39-41 | DOI: 10.36290/csf.2024.007  

The Czech Pharmacopoeia 2023, according to which it is mandatory to proceed from 1.12.2023, is prepared according to the new waiver concept.The change concerns only the Special Part of the European Part of the ČL, which is translated and published only selectively starting from the 2023 ČL.The selection of the articles was made by the Pharmacopoeia Commission of the Ministry of Health in cooperation with experts.The General Part of the European Part of the PRC and the National Part of the PRC are published in full.

Rosemary - its biologically active compounds and their pharmacological effects

Jana Karlíčková, Aneta Klížová

Čes. slov. farm. 2024, 73(1):42-46 | DOI: 10.36290/csf.2024.008  

Rosemary (Rosmarinus officinalis L.) has been used since ancient times for medicinal, cultic, and magic purposes. With the stress and diseases, it is increasingly popular today for many uses in both pharmacy and aromatherapy, as a spice in the kitchen and as a preservative. This plant has many interesting compounds (e.g. rosmarinic and carnosic acid, carnosol), which show a considerable amount of positive pharmacological effects.

Pharmaceutical care in the self-treatment of common urological problems

Jana Šolínová

Čes. slov. farm. 2024, 73(1):48-56 | DOI: 10.36290/csf.2024.009  

In case of self-treatment of common urological disorders, a pharmacist or pharmacy assistant is often the first healthcare professional the patient turns to. Appropriate information should be obtained from the interview with the patient to distinguish between symptoms and conditions suitable for self-treatment and, conversely, to recommend a visit to the physician. The first contact of a patient with healthcare professionals in a pharmacy can also contribute to the detection of more serious diseases. The article deals with the possibilities of pharmaceutical care for a patient with common urological difficulties and the requirement of a recommendation...

Rhinitis and Allergic Rhinitis - self-medication options

Žaneta Tomčalová

Čes. slov. farm. 2024, 73(1):58-65 | DOI: 10.36290/csf.2024.010  

Rhinitis is one of the common diseases that the patient often does not consider necessary to consult a doctor and turns directly to the pharmacist in the pharmacy, who is usually much more accessible to him. It is definitely not appropriate to consider the rhinitis. The pharmacist's role in self-medication therefore consists in trying to determine from the patient's description of his troubles what type of rhinitis it may be, to assess the degree of severity and to decide on the necessity of intervention by a doctor, or the recommendation of a therapeutic procedure with over-the-counter medicinal products. In the case of self-medication, choose the...

Odborné akce pořádané Českou farmaceutickou společnosti České lékařské společnosti J. E. Purkyně, z. s., v roce 2024 Josef Malý

Josef Malý

Čes. slov. farm. 2024, 73(1):66