Preparation and evaluation of spray-dried inhalable microparticles from carrier mixtures

Andrea Peštálová, Karolína Molatová, Jan Gajdziok

Čes. slov. farm. 2023, 72(5):214-222 | DOI: 10.5817/CSF2023-5-214  

The formulation of microparticles composed of a mixture of carriers represents an innovative approach for lung drug delivery of dry powder. The carriers used can significantly influence the properties of the microparticles, such as size, shape, surface area, hygroscopicity, or aggregation, thus improving the aerosolization of the drugs after inhalation. The properties mentioned above are crucial for effective pulmonary therapy. The combination of carriers of a carbohydrate nature and gelling agents is advantageous for controlled drug release. The experimental work aimed to prepare by spray drying and subsequently evaluate ten batches of microparticles...

Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients

Nuhad Mohammed Al-dulaimi, Mahmood Jassim Mohammed, Saad T. Mutlk, Khalid F. Al-Rawi, Hameed Hussein Ali, Bilal J. M. Aldahham, Faisal Al-ani, Osamah Al-ani, Yaqout A. Hamed, Aus T. Ali

Čes. slov. farm. 2023, 72(5):223-232 | DOI: 10.5817/CSF2023-5-223  

Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms,...

Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial

Sadeel A. Shanshal, Mohammad H. Alsaaty, Kh. Harith Al-Qazaz, Radhwan N. Al-Zidan

Čes. slov. farm. 2023, 72(5):233-241 | DOI: 10.5817/CSF2023-5-233  

Alleviating the symptoms of irritable bowel syndrome (IBS) through the addition of probiotics to the treatment of IBS patients appears to be promising. The present randomized clinical trial seeks to assess the efficacy of a multi-strain probiotic product combining two Lactobacillus (L.) strains: L. acidophilus and L. plantarum, in diarrhea-predominant IBS (IBS-D) patients. A randomized, single-blinded clinical trial design was adopted to randomly assign 100 patients into two groups. Patients in group A received standard IBS treatment, whereas Group B patients were treated with probiotics besides the standard treatment. Both groups were...

Therapeutic monitoring of antipsychotics with a focus on lurasidone and its dosing

Zuzana Strašilová, Miroslav Turjap, Jan Juřica

Čes. slov. farm. 2023, 72(5):203-213 | DOI: 10.5817/CSF2023-5-203  

Dose-response relationships are not fully understood for antipsychotics. Especially in the case of multimodal antipsychotics, these relationships cannot be simplified to the level of dopaminergic receptor occupancy alone. In general, for most antipsychotics, there is no linear dose-response relationship. Reasons for this include, among others, pharmacokinetic factors affecting plasma levels. Based on meta-analyses, the doseresponse curve appears to be bell-shaped. However, in the case of some antipsychotics, it appears that even increasing the dose beyond the recommended range could yield further increases in efficacy. It should be stressed that this...

XLIVrd Work Days of the Pharmacological Section of the Czech Nuclear Medicine Society (FaF UK, Hradec Králové, 31. 5. to 2. 6. 2023)

Čes. slov. farm. 2023, 72(5):242-250  

Instructions to the authors

Čes. slov. farm. 2023, 72(5):251-252