Czech and Slovak Pharmacy, 2023 (vol. 72), issue 4
Original Articles
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice
Vadim Tsyvunin, Sergiy Shtrygol', Mariia Mishchenko, Dmytro Lytkin, Andriy Taran, Diana Shtrygol', Tatiana Gorbach
Čes. slov. farm. 2023, 72(4):172-183 | DOI: 10.5817/CSF2023-4-172 
Neuroinflammation plays an important role in the pathogenesis of epilepsy, so it is necessary to clarify the influence of standard antiepileptic drugs as well as adjuvant agents (e.g., cardiac glycoside digoxin, which previously showed a clear anticonvulsant potential) on cyclooxygenase pathway and neuron-specific enolase under the conditions of chronic epileptogenesis. The aim of the article is to determine the effect of digoxin, sodium valproate, and celecoxib per se, as well as the combination of digoxin with sodium valproate on the content of cyclooxygenase 1 and 2 types, prostaglandins E2, F2α, I2, thromboxane B2, 8-isoprostane and...
Study of the anti-inflammatory properties of a thick extract of Tribulus terrestris L.
Saida Yunusova, Yaroslav Rozhkovskyi, Bohdan Prystupa, Svitlana Bohatu
Čes. slov. farm. 2023, 72(4):184-189 | DOI: 10.5817/CSF2023-4-184
The most promising direction in the treatment of chronic prostatitis is the use of medicinal plants and preparations based on them, which contain natural compounds with a broad spectrum of pharmacological activity: anti-inflammatory, antimicrobial, reparative, immunomodulatory, hormone-regulating, antisclerotic, etc., and which can provide a complex therapeutic effect on the course of chronic prostatitis. A promising raw material in this direction is Tribulus terrestris L., a herbal preparation traditionally used to treat erectile dysfunction and atherosclerosis. This experimental work aims to study the anti-inflammatory activity of a thick...
Synthesis, characterization, molecular docking studies of new alkyl derivatives of 5-(2-bromo-4-fluorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol
Roman Shcherbyna, Valerü Kalchenko, Sergii Kulish, Volodymyr Salionov, Liubov Morozova, Natalia Nedorezaniuk, Olha Mazur
Čes. slov. farm. 2023, 72(4):190-200 | DOI: 10.36290/csf.2023.004
The main goal of this article is to present the results of the synthesis of new alkyl derivatives of 5-(2-bromo4-fluorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol and molecular docking studies against COX-1 and COX-2. Previous studies have established a wide range of biological activity of 1,2,4-triazole derivatives. Therefore, it was essential to determine how a new series of 1,2,4-triazole derivatives would provide potential anti-inflammatory activity. To reach the goal, raw alkyl derivatives of 5-(2-bromo-4-fluorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiols ( 2a-2i) from 5-(2-bromo-4-fluorophenyl)-4-ethyl-4H-1,2,4-triazole3-thiol...
Review articles
General intravenous anesthetics - pharmacodynamics, pharmacokinetics and chiral properties
Ružena Čižmáriková, Ladislav Habala, Mário Markuliak
Čes. slov. farm. 2023, 72(4):155-164 | DOI: 10.5817/CSF2023-4-155
In continuation of our published review on general inhalational anesthetics, the current article presents a survey of intravenous agents for general anaesthesia. From chemical point of view these compounds belong to structurally diverse categories, such as barbiturates - thiopental (Sodium pentothal®, Trapanal®, Pentothal®), methohexital (Brevital®), and hexobarbital (Evipan®, Hexenal®, Citopan®, Tobinal®); non-barbiturate derivatives - ketamine (Ketalar® Ketaset®), esketamine (Ketanest®), and etomidate (Amidate®, Hypnomidate®), phenolic derivatives - propofol (Diprivan®); steroid derivatives...
Diazotization titrations in pharmacopoeial quality control of medicines and proposals for their revision in the European Pharmacopoeia
Jan Šubert, Jozef Kolář, Jozef Čižmárik
Čes. slov. farm. 2023, 72(4):165-171 | DOI: 10.5817/CSF2023-4-165
Based on the data in the Ph. Eur., some other newer pharmacopoeias and published experimental papers propose to revise the text of Ph. Eur. 2.5.8. First, it is necessary to specify which of the electrometric methods should be used to indicate the endpoint of diazotization titrations in Ph. Eur. (preferable potentiometry with a platinum indicating electrode). The amount of potassium bromide in the titration solution may be reduced to 1 g, the cooling of the solution before titration may be omitted from the framework procedure, and it may be specified in individual monographs if necessary to obtain accurate and correct results for some medicines. Diazotization...