Investigation of the antimicrobial and antifungal activities of some 1,2,4-triazole derivatives

Yuliia Frolova, Andrii Kaplaushenko, Sameliuk Yurii, Daria Romanina, Liubov Morozova

Čes. slov. farm. 2022, 71(4):149-158 | DOI: 10.5817/CSF2022-4-149  

This article presents the results of the study of the antimicrobial and antifungal properties among 1,2,4-triazole derivatives synthesized at the Department of Physical and Colloidal Chemistry of the Zaporizhzhia State Medical University. Previous studies have established the antimicrobial and antifungal activity of 1,2,4-triazole derivatives. Therefore, it was reasonable to investigate highly effective substances with antimicrobial and antifungal properties among synthesized compounds. In the first stage of our research, acute toxicity prediction was performed. The antimicrobial and antifungal properties were carried out by the method of "serial dilutions"...

Colour and content of some biologically active substances in honey

Jan Šubert, Jozef Kolář, Jozef Čižmárik

Čes. slov. farm. 2022, 71(4):127-134 | DOI: 10.5817/CSF2022-4-127  

This paper highlights the correlations between instrumental measurements of colour and the content of some biologically active organic compounds (especially phenolics and flavonoids) in honey. Sufficiently close correlations may lead to the development of procedures for rapid determination of the content of these substances in honey by colour measurement without the need for more demanding sample preparation.

Selected polyphenolic compounds and their use as a supportive therapy in metabolic syndrome

Jan Soukop, Rostislav Večeřa

Čes. slov. farm. 2022, 71(4):135-139 | DOI: 10.5817/CSF2022-4-135  

Metabolic syndrome is diagnosed mainly in people of economically developed parts of the world and it affects 20-25% of the adult population worldwide. Nowadays, it is also more frequently diagnosed in children and adolescents. In addition to standard treatment that often involves polypharmacotherapy, and thus increases risk of side effects caused by drugdrug interactions, it is appropriate to look for alternative tools to support the treatment of metabolic syndrome components. Natural polyphenolic compounds, usually present in the so-called functional foods, are suitable candidates for that matter, due to the bioactivity and beneficial effects on the...

Neuroactive steroids - new possibilities in the treatment of postpartum depression

Lucia Žigová, Petra Massarová, Katarína Vranecová, Orsolya Hrubá, Adriana Adamičková, Andrea Gažová

Čes. slov. farm. 2022, 71(4):140-148 | DOI: 10.5817/CSF2022-4-140  

Pregnancy and postpartum period are associated with demanding physical and psychological changes that often lead to the development of psychological disorders. Depression is diagnosed in more than one in six women after childbirth. However, the prevalence of postpartum depression can be much higher because many cases are undiagnosed. In the case of severe depression, the patient is switched to pharmacological treatment, with sertraline being the most commonly used for this diagnosis. A new drug used in the treatment of postpartum depression is brexanolone, which was registered by FDA in 2019. The advantage over conventional therapy is its rapid onset...

Vášeň pro krásu lékárníka Mojmíra Helceleta

Miroslava Šudomová

Čes. slov. farm. 2022, 71(4):159-160  

XLIII. pracovní dny Radiofarmaceutické sekce ČSNM Hotel Strážnice, 18. až 20. května 2022

Čes. slov. farm. 2022, 71(4):161-171  

Prof. RNDr. Jan Šubert, CSc. - osemdesiaťročný

J. Čižmárik

Čes. slov. farm. 2022, 71(4):172-173  

Výstava Zahrada vůní aneb Rostliny v parfémech

Miroslava Šudomová

Čes. slov. farm. 2022, 71(4):174