Czech and Slovak Pharmacy, 2022 (vol. 71), issue 2
Original Articles
Community pharmacists and proper administration of inhaled medications
Lucia Masaryková, Tomáš Tesař, Ľubica Lehocká, Zuzana Koblišková, Michaela Čellárová
Čes. slov. farm. 2022, 71(2):43-56 | DOI: 10.5817/CSF2022-2-43 
Inhaled medications are considered a preferred dosage form of medicine to treat respiratory diseases, such as bronchial asthma and chronic obstructive pulmonary disease (COPD), when bronchodilators or, more precisely, controlled drugs for treatment are used. The main objective of our research was to find out community pharmacists' general knowledge of particular inhalation systems (IS) dispensed in pharmacies. All data necessary for the evaluation have been obtained by an anonymous survey questionnaire carried out between September 2020 and January 2021, which was done both in printed form and online. The questionnaire was self-construction, anonymous,...
Beliefs and knowledge related to nutritional supplements among pharmacy students
Charalampos Triantis, Evanthia Asimakopoulou, Konstantina Konidari, Anna Filotheidou, Panagiotis Theodosis-Nobelos
Čes. slov. farm. 2022, 71(2):57-64 | DOI: 10.5817/CSF2022-2-57
A variety of supplement-drug interactions has been identified, and therefore health scientists should be aware of the proper usage of nutritional supplements. The main aim of this study was to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A cross-sectional study was conducted in order to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A literature review on nutritional supplements was conducted in order to develop a 24-item questionnaire, and expert indications established its face and content validity. Τhe sample was comprised of 142 pharmacy students in Cyprus,...
Capillary zone electrophoresis in combination with UV detection for simultaneous determination of tramadol and paracetamol in pharmaceutical and biological samples
Andrea Horniaková, Ondrej Štefánik, Ivana Čižmárová, Michaela Matušková, Peter Mikuš, Juraj Piešťanský
Čes. slov. farm. 2022, 71(2):65-75 | DOI: 10.5817/CSF2022-2-65
The aim of the present study is the development and validation of a simple method based on capillary zone electrophoresis coupled with UV detection for simultaneous determination of tramadol and paracetamol in pharmaceutical and biological samples. The background electrolyte was composed of 50 mM ammonium carbonate, which is a type of a non-conventional electrolyte system. The developed method was characterized by suitable validation parameters, such as linearity (coefficient of determination r2 ≥ 0,995), selectivity or the limit of detection at the level of 0.25 - 0.5 μg/ml. Acceptable values of accuracy and precision were obtained, which were...
Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures
Vadim Tsyvunin, Sergiy Shtrygol', Mariia Mishchenko, Diana Shtrygol'
Čes. slov. farm. 2022, 71(2):76-86 | DOI: 10.5817/CSF2022-2-76
The prevalence of epilepsy in the world population together with a high percentage of patients resistant to existing antiepileptic drugs (AEDs) stimulates the constant search for new approaches to the treatment of the disease. Previously a significant anticonvulsant potential of cardiac glycoside digoxin has been verified by enhancing a weak activity of AEDs in low doses under screening models of seizures induced by pentylenetetrazole and maximal electroshock. The aim of the present study is to investigate the influence of digoxin at a sub-cardiotonic dose on the anticonvulsant activity of valproate, levetiracetam, and topiramate in models of primary...