Czech and Slovak Pharmacy, 2021 (vol. 70), issue 2
Original Articles
Causes and interventions of medication errors in healthcare facilities
Jan Neugebauer, Valérie Tóthová, Ivana Chloubová, Hana Hajduchová, Iva Brabcová, Radka Prokešová
Čes. slov. farm. 2021, 70(2):43-50 | DOI: 10.5817/CSF2021-2-43 
A medication error is one of the most common causes of patients' complications or death in healthcare facilities. In the United States, 7,000 out of 9,000 patients die because of medication errors each year. Known factors are generally divided into four groups - human factor, intervention, technical factor, and system.Our study includes 17 studies from the OVID, Web of Science, Scopus, and EBSCO databases, in the range of 2015-2020. After a selection of professional publications, 2 categories were created - factors leading to medication errors and interventions to reduce medication error and testing their effectiveness.It has been found that...
Synthesis and HPLC enantioseparation of novel derivatives of 3-alkoxy-4-hydroxyphenylalkanones of a potential α/β-blocker type
Ružena Čižmáriková, Ladislav Habala, Jindra Valentová, Dana Šmátralová
Čes. slov. farm. 2021, 70(2):51-58 | DOI: 10.5817/CSF2021-2-51
The present paper reports the synthesis of a series of seven compounds with a hetero aminopropanol chain. The compounds were prepared by the conversion of 3-alkoxy-4-hydroxyphenyl alkanones with 2-chloromethyl oxirane and subsequent reaction of the products with heterocyclic amines (pyrrolidine, azepane, 4-methylpiperazine and 2-methoxyphenyl piperazine). The target compounds were synthesized in the form of racemates. The purity of the products was confirmed by thin layer chromatography and their IR, UV-VIS and 1H-NMR spectra were recorded. Enantioseparation of the racemic products was accomplished by HPLC on a Chiralpak AD chiral chromatographic...
Investigation of the anabolic activity of dry extracts of Iris hungarica leaves and rhizomes on the model of hydrocortisone-induced protein catabolism
Viktoria Rybak, Gunel Kerimova, Viktoria Korol
Čes. slov. farm. 2021, 70(2):59-65 | DOI: 10.5817/CSF2021-2-59
This article presents the results of the study of the anabolic effect of dry extracts of Iris hungarica leaves and rhizomes on the model of hydrocortisoneinduced protein catabolism. Previous studies have established the presence of anabolic activity of dry extracts of Iris hungarica leaves and rhizomes in intact animals. Therefore, it was reasonable to study the effect of the experimental extracts on the state of protein metabolism, which is regulated by glucocorticoids. The model of hydrocortisoneinduced protein catabolism was used to determine anabolic activity for dry extracts of Iris hungarica leaves and rhizomes at a dose of 150...
Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach
Oleksii Yakovenko, Tetiana Kolisnyk, Lena Ruban, Natalia Fil
Čes. slov. farm. 2021, 70(2):66-78 | DOI: 10.5817/CSF2021-2-66
The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method. To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested. The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ™ 721 (fillers); Plasdone™ S-630, Kollidon®...