Czech and Slovak Pharmacy, 2020 (vol. 69), issue 4
Original Articles
Collagen in combination with the acid form of carboxymethylcellulose in the form of a nonwoven textile as a modern wound dressing - formulation, preparation and evaluation
Kateřina Tenorová, Ruta Masteiková, Jana Jarábková, David Vetchý, Jurga Bernatonienė
Čes. slov. farm. 2020, 69(4):163-171 | DOI: 10.36290/csf.2020.024 
The acid form of carboxymethylcellulose (HCMC) is less known than its sodium salt (NaCMC). However, it is commonly used as a sorbent for chromatographic columns and has a number of valuable properties for its use in wound care. As a wound dressing in the form of hydrofibers, it is already commercially available on our market. Collagen, the most abundant protein in the human body, fulfils both a building and a physiological function in the body, also has an irreplaceable place in the treatment of wounds. It is important in the process of wound healing and is used in wound therapy in various forms. It exhibits very good film-forming properties as well,...
Application of inhaled drugs from the pharmacist's point of view
Lucia Masaryková, Petra Polaščíková
Čes. slov. farm. 2020, 69(4):172-184 | DOI: 10.36290/csf.2020.025
The basis of asthma and chronic obstructive pulmonary disease (COPD) treatment is inhalation therapy, which brings several benefits and its success is based on the correct inhalation technique. Aim: The primary aim of the research was to find out what percentage of patients could apply their medicines properly, what inhalation systems were preferred in the treatment of these respiratory diseases, what most common mistakes in the inhalation technique patients made when using inhalers as well as what was patients' approach to the possibility of being educated by a community pharmacist. Methods: Essential data to accomplish the goal...
Simultaneous determination of amoxicillin and potassium clavulanate in combined medicinal forms: procedure transfer from HPLC to UPLC
Anna O. Dobrova, Olga S. Golovchenko, Ivan V. Bezruk, Liudas Ivanauskas, Victoriya Georgiyants
Čes. slov. farm. 2020, 69(4):186-193 | DOI: 10.36290/csf.2020.026
This article presents the results of transferring a high-performance liquid chromatography (HPLC) procedure for the assay of amoxicillin and potassium clavulanate in tablets to the ultra-performed liquid chromatography (UPLC) conditions. Since the State Pharmacopoeia of Ukraine (SPhU) does not contain the monograph for the simultaneous analysis of amoxicillin and clavulanic acid, the British Pharmacopoeia procedure was used. Parameters of the procedure were optimized to fit the UPLC and to make a better performance. Transfer of the method to the UPLC conditions allowed to shorten the run time from 15 min to 7.5 min, which makes the process less time-consuming...
Review articles
Vaccines from the perspective of a pharmacist
Aleš Franc
Čes. slov. farm. 2020, 69(4):151-162 | DOI: 10.36290/csf.2020.023
The field of development, production and safety of vaccines has recently come under the public eye. The aim of this review article is not to provide comprehensive information on the development and production of vaccines, which would not be possible even in a limited space. Its purpose is to outline a brief overview of the principles, development, and production of basic types of vaccines and point out the benefits and risks from the perspective of a pharmacist. He can participate not only in basic research, but his role is mainly in the formulation of a dosage form, registration of a vaccine, its distribution, and educational activities towards the...
Short Communications
Composition of fatty acids in Centaurea cyanus (L.)
Iryna B. Pietkova, Liana M. Unhurian, Liliia M. Horiacha, Viktoriia S. Kyslychenko, Iryna O. Zhuravel, Viiktoria Yu. Kuznietsova, Oleksandr I. Panasenko
Čes. slov. farm. 2020, 69(4):194-197 | DOI: 10.36290/csf.2020.027
The presented study shows the composition of fatty acids (FA) in flowers and herb of wild and cultivated cornflower (Centaurea cyanus (L.)). The analysis was performed by gas chromatography (GC) with a method using internal normalization. Together 13 fatty acids were identified in both types of cornflower herb. Unsaturated fatty acids, particularly, linoleic, linolenic, and oleic acids, were prevailing in cultivated cornflower flowers and herb, as well as in wild cornflower flowers. Palmitic acid was the most abundant saturated FA.