Czech and Slovak Pharmacy, 2020 (vol. 69), issue 3
Original Articles
Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone
Lucie Černá, Zuzana Baďo, Petra ©alamúnová, Karel ©mejkal, Jaroslav Hanuą, Jan Hoąek
Čes. slov. farm. 2020, 69(3):130-136 | DOI: 10.36290/csf.2020.020 
Geranylated flavanone diplacone is a flavanone isolated from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water. Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs). GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of β-(1→3)/β-(1→6) glucan mainly. The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical...
The study of hypoglycemic and hypolipidemic activity of Camelina sativa (L.) Crantz extracts in rats under conditions of high-fructose diet
Tetiana O. Tsykalo, Serhiy D. Trzhetsynskyi
Čes. slov. farm. 2020, 69(3):137-142 | DOI: 10.36290/csf.2020.021
The present article discusses the results of the study of the pharmacological activity of plant extracts from Camelina sativa (L.) Crantz: total herb extract (ECS) and oil from seeds (OCS). ECS was obtained from non-fat raw materials by the method of fractional maceration with 70% ethanol. OCS was obtained by means of extraction in a Soxhlet apparatus. Possible hypoglycemic activity of the extracts and dose selection were evaluated by primary pharmacological screening. Maximum hypoglycemic activity for ECS and OCS at a dose of 200 mg/kg was detected. A deeper study of the hypoglycemic and hypolipidemic properties of the extracts was performed...
A pharmacodynamic study of a new gel containing an extract of Aloe vera and an extract of oak bark for potential treatment of periodontal diseases
N. A. Tsubanova, D. S. Zhurenko
Čes. slov. farm. 2020, 69(3):143-148 | DOI: 10.36290/csf.2020.022
The article presents the results of a pharmacodynamic study of a new gel containing an extract of Aloe vera and an extract of oak bark under the condition of destructive inflammatory periodontal diseases. Pharmacodynamics of the new gel was studied by the following methods: antimicrobial effect - by diffusion method in agar gel (compared product - Metrogyl denta® gel); reparative effect - on the model of linear cut wounds (compared product - Calendula ointment); anti-inflammatory activity - on the model of acute carrageenan-induced inflammation (compared product - Diclofenac natrium gel 5%). It has been established...
Review articles
Ingavirin might be a promising agent to combat Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2)
Ivan Malík, Gustáv Kováč, Tereza Padrtová, Lucia Hudecová
Čes. slov. farm. 2020, 69(3):107-111 | DOI: 10.36290/csf.2020.017
The Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-19 (COVID-19) pandemic, caused by the virus, have changed the world in just half a year. Lack of effective treatment, coupled with etiology of COVID-19, has resulted in more than 500,000 confirmed deaths at the time of writing, and the global economy is at an unseen unprecedented low level with unknown near- and long-term consequences. Ingavirin has been considered a non-toxic broad-spectrum antiviral with a complex mechanism of action. The molecule was originally designed for the prophylaxis and treatment of flu caused by both Influenza A and B viruses and for the treatment...
Medicinal products with controlled drug release for local therapy of inflammatory bowel diseases from perspective of pharmaceutical technology
Kateřina Kubová
Čes. slov. farm. 2020, 69(3):112-120 | DOI: 10.36290/csf.2020.018
The aim of this article is to introduce the basic design of used medicinal products with controlled drug release for the treatment of inflammatory bowel diseases and to clarify their behaviour in gastrointestinal tract from the perspective of pharmaceutical technology. Specifically, it focuses on pharmaceutical drugs containing 5-aminosalicylic acid (Asacol®, Pentasa®, Salofalk®) and budesonide (Budenofalk®, Cortiment®, Entocort®). As a part of this paper, basic recommendations and practical information that can be used in clinical practice are also given.
Metal complexes in medicine and pharmacy - the past and the present III
Ladislav Habala, Jindra Valentová
Čes. slov. farm. 2020, 69(3):121-129 | DOI: 10.36290/csf.2020.019
Bioactive metal complexes represent a promising and rapidly evolving area of pharmacotherapy. After the first part of our survey on metallopharmaceuticals dealing with antimicrobial activity of metal complexes and their application in diagnostics and the second part dedicated to anticancer properties of these compounds, this third and last part of the review focuses on several other applications of metals in therapy (mainly on the therapy of rheumatoid arthritis, some mental diseases, diabetes, as well as on chelation therapy). Following a brief account of the historical development of clinical use of the respective category of drugs, their chemical...