Double-coated pellets with semipermeable ethylcellulose coating for detection of cholinesterase inhibitors

Jiří Zeman, Sylvie Pavloková, David Vetchý, Vladimír Pitschmann

Čes. slov. farm. 2020, 69(1):24-32 | DOI: 10.36290/csf.2020.003  

Currently, nerve agents are often used in terrorist attacks or assassinations. In such cases, it is necessary to detect them quickly, accurately and easily right in the field. Detection tubes, which are small devices containing pellets with immobilized cholinesterase and detection reagents, meet these conditions. Their detection mechanism is based on a highly sensitive enzymatic Ellman reaction, when in the absence of cholinesterase inhibitors the pellets develop a visible yellow color, whereas in their presence the carriers retain the original color. The rate of reaction, its sensitivity and the distinct color transition are the key points of the...

Development and uniformity evaluation of low-dose medicated chewing gums prepared by compression method

Yuliia Maslii, Olena Ruban, Olga Yevtifieieva, Volodymyr Hrudko, Svitlana Gureyeva, Andriy Goy, Tetiana Kolisnyk

Čes. slov. farm. 2020, 69(1):33-42 | DOI: 10.36290/csf.2020.004  

The aim of this work was to develop medicated chewing gums (MCGs) containing 10 mg of lysozyme hydrochloride (LH) and 20 mg of ascorbic acid (AsA) obtained by the compression method with Health in Gum^® (HiG^®) PWD 01 as a compressible gum base. Because of a low content of active ingredients, it was essential to choose the way of adding them to the tableting mass and evaluate their distribution homogeneity in the dosage units. The blends for compression were prepared by two methods: the first one was simple mixing of all components; the second one included the step of wet granulation of a three-component mixture - LH, sucralose...

Investigation of thioctic acid, magnesium stearate and pyridoxine hydrochloride compatibility

Maksym Almakaiev, Olga Vashchenko, Dmitry Sofronov, Liliia Budianska, Longin Lisetski

Čes. slov. farm. 2020, 69(1):43-47 | DOI: 10.36290/csf.2020.005  

To identify possible interactions of components in dosage forms, studies are usually carried out at the stage of pharmaceutical development. Such studies can predict compatibility of active pharmaceutical ingredients and excipients in order to optimize drug formulation and certain parameters of technological process. Compatibility of some components of a newly developed neuroprotective medicinal product 'Neuronucleos', namely, thioctic acid, pyridoxine hydrochloride, magnesium stearate and magnesium lactate, was studied by means of differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). No interactions were observed...

Metal complexes in medicine and pharmacy - the past and the present II

Ladislav Habala, Jindra Valentová

Čes. slov. farm. 2020, 69(1):3-16 | DOI: 10.36290/csf.2020.001  

Therapy of malignant tumors is among the oldest and at the same time the most promising application areas of therapeutic metal complexes. The second part of our survey on metallopharmaceuticals deals with historical development and current state of coordination compounds in cancer therapy. It starts with the most famous and most successful metallodrug - cisplatin. After a brief account of the discovery of the anticancer properties of this substance follows the discussion of its chemical properties, toxicity, clinical application and resistance. Hereafter, complexes of other metals along with innovative research directions are addressed. The aim of...

Pharmacokinetic aspects of beta-lactam antibiotic therapy in intensive care unit patients: A one-center experience with TDM

Kateřina Sadilová, Milada Halačová, Dalibor Černý

Čes. slov. farm. 2020, 69(1):17-23 | DOI: 10.36290/csf.2020.002  

Early and appropriate antibiotic therapy remains the key intervention for successful treatment of infection in critically ill patients, particularly in the current era of increasing antibiotic resistance. Optimization of the antimicrobial dosing regimens to achieve therapeutic plasma concentrations and concentrations at the site of infection is crucial for maximizing the therapeutic response and minimizing the risk of organ toxicity and is also an important tool to avoid the resistance emergence. Beta-lactam antibiotics have been considered relatively safe and, as opposed to aminoglycosides, therapeutic drug monitoring as a tool conventionally used...

K životnému jubileu pani doc. RNDr. Zuzany Vitkovej, CSc.

J. Čižmárik

Čes. slov. farm. 2020, 69(1):52-55  

Životné jubileum prof. RNDr. Daniela Grančaia, CSc.

J. Čižmárik

Čes. slov. farm. 2020, 69(1):53-54  

Zomrel Alois Borovanský

J. Čižmárik

Čes. slov. farm. 2020, 69(1):55  

The amino acid and carbohydrate composition of the herb and roots of Smallanthus sonchifolius

Olga V. Demeshko, Elena V. Krivoruchko, Victoria I. Volochai, Victoria A. Samoilova, Vladimir V. Kovalev

Čes. slov. farm. 2020, 69(1):48-51 | DOI: 10.36290/csf.2020.006  

The free and protein-bound amino acid composition of the herb and roots of Smallanthus sonchifolius was analyzed by HPLC method. Fourteen free and fifteen protein-bound amino acids were determined in yacon herb, and three free and fourteen protein-bound amino acids in the roots. Among the free amino acids, proline (0.44 µg/mg) and aspartic acid (0.12 µg/mg) were dominant in the herb and proline (0.28 µg/mg) in the roots. Among the protein-bound amino acids, aspartic acid (18.58 µg/mg), glutamic acid (16.33 µg/mg) and proline (14.52 µg/mg) prevailed in the herb, and proline (3.14 μg/mg) in the roots. Fructose,...