Selection of technological parameters for the preparation of the combined oral solution Maglycimet™

Daria V. Snehyrova, Liudmila G. Almakaieva, Olexandra S. Kran

Čes. slov. farm. 2019, 68(3):119-124 | DOI: 10.36290/csf.2019.013  

The problem of magnesium deficiency is an urgent issue of modern humanity. The population of many countries has a tendency to reduce the intake of this element in the daily diet. Its level decreases due to stress, inappropriate lifestyle, increased excretion from the body because of influence of medicines, etc. Therefore, creation of magnesium-containing medicines is a perspective scientific area. Currently at the pharmaceutical market, combination drugs with a multi-therapeutic effect are preferred. We have developed a technology for the preparation of the combined oral solution named Maglycimet^™, which consists of the following active...

Theory and practice of pharmacopoeial control of quality of drugs and excipients IX. The problem of tolerance limits for the content of active substances and excipients in the European Pharmacopoeia (Ph. Eur.)

Jan Šubert, Jozef Kolář

Čes. slov. farm. 2019, 68(3):91-94 | DOI: 10.36290/csf.2019.011  

Content tolerance limits should respect the acceptable variation in the content of the active substance or excipient from its production and the variability of the results of the analytical procedure prescribed to determine the content by the appropriate pharmacopoeia. This usually prevails in the active substances and excipients. They should be derived statistically based on the precision of the prescribed analytical method determined by the interlaboratory test. Calculations from published precision characteristics show that some tolerance intervals for the active substance content are probably too narrow in Ph. Eur. This can lead to erroneous decisions...

Schisandra chinensis and its phytotherapeutical applications

Michal Rybnikář, Karel Šmejkal, Milan Žemlička

Čes. slov. farm. 2019, 68(3):95-118 | DOI: 10.36290/csf.2019.012  

Schisandra (Schisandra chinensis) has been used for centuries as a plant of traditional Chinese medicine. Its biological activity and pharmacological use are associated with dibenzocyclooctadiene lignans, while specific polysaccharides may also be involved. The lignans of schisandra are genus-specific. Their activity has been investigated in hundreds of studies that have confirmed adaptogenic effects, central nervous system stimulation, hepatoprotective effects and potential anticancer potential. This summary review of the literature synthesizes the current state-of-the-art in research on bioactivities of schisandra constituents, description...

XLI. pracovní dny Radiofarmaceutické sekce České společnosti nukleární medicíny ČLS JEP

Čes. slov. farm. 2019, 68(3):125-132  

Zemřel pan docent RNDr. Pavel Komárek, PhD. † 8. července 2019

Čes. slov. farm. 2019, 68(3):133